Translational Molecular Imaging

Introduction

Head: David Lewis

Lewis David 0054

Nuclear imaging techniques have gained wide acceptance in recent years for monitoring response to cancer therapy at the molecular level. Nuclear imaging using specific probes allows non-invasive, longitudinal assessment of biological processes, such as tumour metabolism, cell proliferation, angiogenesis, hypoxia and receptor dynamics. The Nuclear Imaging facility provides preclinical PET/MR imaging support to a range of in vivo research projects.

PET/MR imaging has achieved remarkable momentum in the areas of preclinical research and translational imaging. This novel technology utilises the functional imaging capabilities offered by both PET and MR modalities, using the MR data as anatomic information amended by functional data from PET. At present, PET/MR is probably the most strongly emerging imaging platform in cancer research and it is anticipated that over the next few years, it will also show its potential for providing novel options in critical clinical diagnosis.

Link to David Lewis's research page

Lab Report

icon Translational Molecular Imaging Report

Key Publications

Zmuda F, Blair A, Liuzzi M, Malviya G, Chalmers AJ, Lewis D, Sutherland A, Pimlott SL. An 18F-labeled poly(ADP-ribose) polymerase positron emission tomography imaging agent. J Med Chem 2018; 61: 4103-14.

Blair A, Zmuda F, Malviya G, Tavares AAS, Tamagnan GD, Chalmers AJ, Dewar D, Pimlott SL, Sutherland A. A novel 18F-labelled high affinity agent for PET imaging of the translocator protein. Chem Sci, 2015; 6: 4772–7.

Zmuda F, Malviya G, Blair A, Boyd M, Chalmers AJ, Sutherland A, Pimlott SL. Synthesis and evaluation of a radioiodinated tracer with specificity for poly(ADP-ribose) polymerase-1 (PARP-1) in vivo. J Med Chem 2015; 58(21):8683-93.

Morran DC, Wu J, Jamieson NB, Mrowinska A, Kalna G, Karim SA, Au AY, Scarlett CJ, Chang DK, Pajak MZ; Australian Pancreatic Cancer Genome Initiative (APGI), Oien KA, McKay CJ, Carter CR, Gillen G, Champion S, Pimlott SL, Anderson KI, Evans TR, Grimmond SM, Biankin AV, Sansom OJ, Morton JP.  Targeting mTOR dependency in pancreatic cancer.  Gut. 2014;63(9):1481-9.

Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, Adams PD, Anderson KI, Gottlieb E, Sansom OJ, Ryan KM.  p53 status determines the role of autophagy in pancreatic tumour development.  Nature. 2013;504(7479):296-300. 

Recent Publications

2018

Serrao EM, Kettunen MI, Rodrigues TB, Lewis DY, Gallagher FA, Hu DE, Brindle KM. Analysis of (13) C and (14) C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with (13) C- and (14) C-labeled pyruvate. NMR Biomed 2018;31(5):e3901. doi: 10.1002/nbm.3901

Zmuda F, Blair A, Liuzzi MC, Malviya G, Chalmers AJ, Lewis D, Sutherland A, Pimlott SL. An (18)F-Labeled Poly(ADP-ribose) Polymerase Positron Emission Tomography Imaging Agent. J Med Chem 2018;61(9):4103-14. doi: 10.1021/acs.jmedchem.8b00138

2017

Neves AA, Xie B, Fawcett S, Alam IS, Witney TH, de Backer MM, Summers J, Hughes W, McGuire S, Soloviev D, Miller J, Howat WJ, Hu DE, Rodrigues TB, Lewis DY, Brindle KM. Rapid Imaging of Tumor Cell Death in vivo using the C2A domain of Synaptotagmin-I. J Nucl Med 2017; 58: 881–7

Brindle KM, Izquierdo-Garcia JL, Lewis DY, Mair RJ, Wright AJ. Brain Tumor Imaging. J Clin Oncol 2017; 35: 2432–38

2016

Vis R, Malviya G, Signore A, Grutters JC, Meek B, van de Garde EMW, Keijsers RGM. 99mTc labelled anti-TNF-α antibody for the imaging of disease activity in patients with pulmonary sarcoidosis. Eur Respir J 2016; 47(4):1198-207

Malviya G, Nayak T, Gerdes C, Dierckx RA, Signore A, de Vries EF. Isolation and 111In-Oxine Labeling of Murine NK Cells for Assessment of Cell Trafficking in Orthotopic Lung Tumor Model. Mol Pharm 2016; 13(4):1329-38

2015

Blair A, Zmuda F, Malviya G, Chalmers AJ, Dewar D, Pimlott SL, Sutherland A. A novel 18F-labelled high affinity agent for PET imaging of the translocator protein. Chem Sci 6: 4772–7, 2015

Galli F, Lanzolla T, Pietrangeli V, Malviya G, Ricci A, Bruno P, Ragni P, Scopinaro F, Mariotta S, Signore A. In vivo evaluation of TNF-alpha in the lungs of patients affected by sarcoidosis. Biomed Res Int 2015: 401341, 2015

Galli F, Rapisarda AS, Stabile H, Malviya G, Manni I, Bonanno E, Piaggio G, Gismondi A, Santoni A, Signore A. In Vivo Imaging of Natural Killer Cell Trafficking in Tumors. J Nucl Med 56: 1575-80, 2015

Zmuda F, Malviya G, Blair A, Boyd M, Chalmers AJ, Sutherland A, Pimlott SL. Synthesis and Evaluation of a Radioiodinated Tracer with Specificity for Poly(ADP-ribose) Polymerase-1 (PARP-1) in Vivo. J Med Chem 2015. Doi: 10.1021/acs.jmedchem.5b01324. Epub 2015 Oct 27

2014

Morran DC, Wu J, Jamieson NB, Mrowinska A, Kalna G, Karim SA, Au AY, Scarlett CJ, Chang DK, Pajak MZ, Oien KA, McKay CJ, Carter CR, Gillen G, Champion S, Pimlott SL, Anderson KI, Evans TR, Grimmond SM, Biankin AV, Sansom OJ, Morton JP. Targeting mTOR dependency in pancreatic cancer. Gut 63: 1481-9, 2014

Malviya G, Galli F, Sonni I, Signore A. Imaging T-lymphocytes in inflammatory diseases: a nuclear medicine approach. Q J Nucl Med Mol Imaging 58: 237-57, 2014

Malviya G, Signore A. Infection and inflammation imaging. Nucl Med Biol 41: 488, 2014

Signore A, de Vries EFJ, Galli F, Malviya G. Applications of molecular small-animal imaging in inflammation and infection. In: Molecular Imaging of Small Animals: Instrumentation and Applications. Springer, New York, USA (ISBN: 9781493908943)

Group Members

Lewis lab 0050

Staff Scientist

Gaurav Malviya

Scientific Officers

Caroline Findlay
Emma Johnson
Agata Mrowinska

Research

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Read more about the Research Groups working at the Beatson Institute.

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Seminars

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Find out more about our seminars including our Distinguished Seminar Programme.

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