Danny Huang's group publish structure of c-Cbl

Danny Huang and his group have used X-ray crystallography techniques to determine the 3D structure of a protein called c-Cbl, which helps prevent the unreguated cell growth that leads to cancer. The researchers were able to show that c-Cbl changes shape when it is switched on or off, and understanding this could lead to better anti-cancer treatments. Work in the lab is funded by Cancer Research UK .

The work was published in Nature Structural & Molecular Biology:
Dou H, Buetow L, Hock A, Sibbet GJ, Vousden KH, Huang DT. Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl. Nature Strucutral & Molecular Biology doi:10.1038/nsmb.2231, publsihed online 22 Jan 2012.

More details can be found at:
BBC News Scotland

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