David Lewis - Molecular Imaging

Introduction

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Cancer cells are metabolically reprogrammed to provide the energy and biomass required to proliferate. The resulting metabolic phenotype is driven by genetic mutations and a nutrient-deprived microenvironment. Differing mutations and substrate availability create a dynamic and metabolically heterogeneous tumour. This heterogeneity drives tumour recurrence, metastasis and drug resistance leading to a poor clinical outcome for cancer patients.

Molecular imaging can non-invasively measure the spatial and temporal dynamics of cancer metabolism. Research in our group uses state-of-the art PET/MR imaging, metabolomics and genomics to understand the drivers and consequences of metabolic heterogeneity in living tumours. The goal of this research is to develop methods to non-invasively classify tumours and to direct cancer treatment.

Radionuclide imaging of lung tumour development (place cursor over image to play video):

d lewis image 

Postdoctoral position available with Dr Lewis - see Careers for more details, closing date 12 May 2017

Young Investigator of the Year Award Finalist (World Molecular Imaging Congress, New York), 2016

Lab Report

icon Nuclear Imaging Report

Key Publications

Neves AA, Xie B, Fawcett S, Alam IS, Witney TH, de Backer MM, Summers J, Hughes W, McGuire S, Soloviev D, Miller J, Howat WJ, Hu D-e, Rodrigues TB, Lewis DY, Brindle KM. (2017) Rapid Imaging of Tumor Cell Death in vivo using the C2A domain of Synaptotagmin-I. Journal of Nuclear Medicine (published ahead of print doi: 10.2967/jnumed.116.183004).

Lewis DY, Soloviev D, Brindle KM (2015). Imaging tumor metabolism using positron emission tomography. The Cancer Journal 21(2): 129-136.

Irkle A, Vesey AT, Lewis DY, Skepper JN, Bird JL, Dweck MR, Joshi FR, Gallagher FA, Warburton EA, Bennett MR, Brindle KM, Newby DE, Rudd JH, Davenport AP (2015). Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography. Nature Communications 6: 7495.

Lewis DY, Boren J, Shaw GL, Bielik R, Ramos-Montoya A, Larkin TJ, Martins CP, Neal DE, Soloviev D, Brindle KM (2014). Late Imaging with [1-11C]Acetate Improves Detection of Tumor Fatty Acid Synthesis with PET. Journal of Nuclear Medicine 55(7): 1144-1149.

Patrick PS, Hammersley J, Loizou L, Kettunen MI, Rodrigues TB, Hu DE, Tee SS, Hesketh R, Lyons SK, Soloviev D, Lewis DY, Aime S, Fulton SM, Brindle KM (2014). Dual-modality gene reporter for in vivo imaging. Proceedings of the National Academy of Sciences 111(1): 415-420.

Gallagher FA, Bohndiek SE, Kettunen MI, Lewis DY, Soloviev D, Brindle KM (2011). Hyperpolarized 13C MRI and PET: in vivo tumor biochemistry. Journal of Nuclear Medicine 52(9): 1333-1336.

Biography

Education and qualifications

2008: PhD Neuropsychopharmacology, University of Strathclyde, Glasgow, UK
2003: BSc Pharmacology (First Class Honours), University of Glasgow, Glasgow, UK

Appointments

2017-present: Group Leader, Cancer Research UK Beatson Institute, Glasgow, UK
2012-2016: Senior Postdoctoral Fellow, Radionuclide Imaging Facility, Cancer Research UK Cambridge Institute, University of Cambridge, UK
2011-2016: Research Associate, Corpus Christi College, University of Cambridge, UK
2009-2016: Honorary Visiting Researcher, Department of Biochemistry, University of Cambridge, UK
2015: 'CRUK Awarded' Visiting Scholar, Molecular Imaging Program at Stanford, Stanford University School of Medicine, USA
2009-2012: Senior Postdoctoral Research Fellow, Cambridge Research Institute, Cancer Research UK
2008-2009: Research Fellow in Neuroscience, Translational Medicine Research Collaboration, University of Glasgow, UK
2007-2008: Study Director, CNS and Rodent Safety Pharmacology, Aptuit Limited, Riccarton, UK
2003-2008: Graduate Teaching Assistant, Department of Pharmacology, University of Strathclyde, UK

Honours and awards

Young Investigator of the Year Award Finalist (World Molecular Imaging Congress, New York), 2016
Industry Sponsored Award Winner (World Molecular Imaging Congress, New York), 2016
Research Travel Award (CRUK), 2015
John J. Lewis Award (University of Glasgow) for outstanding examination performance, 2003

Recent Publications

2017

Brindle KM, Izquierdo-Garcia JL, Lewis DY, Mair RJ, Wright AJ (2017) Brain Tumor Imaging. J Clin Oncol, in press

Neves AA, Xie B, Fawcett S, Alam IS, Witney TH, de Backer MM, Summers J, Hughes W, McGuire S, Soloviev D, Miller J, Howat WJ, Hu D-e, Rodrigues TB, Lewis DY, Brindle KM. Rapid Imaging of Tumor Cell Death in vivo using the C2A domain of Synaptotagmin-I. Journal of Nuclear Medicine (published ahead of print doi: 10.2967/jnumed.116.183004), 2017

2016

Heinzmann K, Honess DJ, Lewis DY, Smith DM, Cawthorne C, Keen H, Heskamp S, Schelhaas S, Witney TH, Soloviev D, Williams KJ, Jacobs AH, Aboagye EO, Griffiths JR, Brindle KM. The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models. EJNMMI Research 6(1): 63, 2016

Serrao EM, Kettunen MI, Rodrigues TB, Dzien P, Wright AJ, Gopinathan A, Gallagher FA, Lewis DY, Frese KK, Almeida J, Howat WJ, Tuveson DA, Brindle KM. MRI with hyperpolarised [1 13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model. Gut 65, 465-475, 2016

2015

Lewis DY, Soloviev D, Brindle KM. Imaging tumor metabolism using positron emission tomography. The Cancer Journal 21(2): 129-136, 2015

Irkle A, Vesey AT, Lewis DY, Skepper JN, Bird JL, Dweck MR, Joshi FR, Gallagher FA, Warburton EA, Bennett MR, Brindle KM, Newby DE, Rudd JH, Davenport AP. Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography. Nature communications 6: 7495, 2015

2014

Lewis DY, Boren J, Shaw GL, Bielik R, Ramos-Montoya A, Larkin TJ, Martins CP, Neal DE, Soloviev D, Brindle KM. Late Imaging with [1-11C]Acetate Improves Detection of Tumor Fatty Acid Synthesis with PET. Journal of nuclear medicine 55(7): 1144-1149, 2014

Lewis DY, Champion S, Wyper D, Dewar D, Pimlott S. Assessment of [125I]WYE-230949 as a novel histamine H3 receptor radiopharmaceutical. PloS One 9(12): e115876, 2014

Patrick PS, Hammersley J, Loizou L, Kettunen MI, Rodrigues TB, Hu DE, Tee SS, Hesketh R, Lyons SK, Soloviev D, Lewis DY, Aime S, Fulton SM, Brindle KM. Dual-modality gene reporter for in vivo imaging. Proceedings of the National Academy of Sciences of the United States of America 111(1): 415-420, 2014

2012

Soloviev D, Lewis D, Honess D, Aboagye E (2012). [18F]FLT: an imaging biomarker of tumour proliferation for assessment of tumour response to treatment. European journal of cancer 48(4): 416-424, 2012

Lab Members

Research

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Seminars

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Find out more about our seminars including our Distinguished Seminar Programme.

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