Imran Ahmad - Prostate Cancer Biology

Senior Clinical Lecturer in Urology, University of Glasgow

Cancer Research UK Clinician Scientist

Introduction

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Prostate cancer is a leading cause of cancer mortality in men in the western world. Identifying and understanding the pathways that drive advanced and treatment-resistant prostate cancer will provide important information that will allow prognostication and individualised patient treatments.

Androgens have been found to be important for prostate cancer progression and androgen deprivation therapy is usually effective at initially controlling the disease. In many cases, however, there is a recurrent castration-resistant phase, for which there is no effective treatment.

My current research interest is in understanding the mechanisms of treatment-resistance in advanced prostate cancer. Work in my laboratory uses state-of-the-art in vivo models in conjunction with patient samples to interrogate the disease processes in advanced and treatment-resistant prostate cancer. This work will help to provide information on drivers of prostate cancer progression and to identify novel biomarkers of disease and/or drug targets to treat the disease.

As an Honorary Consultant Urological and Robotic Surgeon based at the Queen Elizabeth University Hospital in Glasgow, I currently perform robotic surgery for localised/locally advanced prostate cancer.

Lab Report

Key Publications

Ahmad I, Patel R, Singh LB, Nixon C, Seywright M, Barnetson RJ, Muller WJ, Edwards J, Sansom OJ, Leung HY. "HER2 overcomes PTEN (loss) induced Senescence to cause Aggressive Prostate Cancer". PNAS 2011; 208(39): 16392-97.

Biography

Education and qualifications

2015: FEBU, European Board of Urology
2014: FRCS (Urol), Royal College of Surgeons of England (RCSEng)
2010: PhD in Bladder Cancer Biology, 'The role of Wnt Signalling in Urothelial Cell Carcinoma', CRUK Beatson Institute/University of Glasgow
2005: MRCS, RCSEng
2003: MB ChB, University of Glasgow
2001: BSc (MedSci) Hons in Anatomical Sciences (Class 1:1), University of Glasgow

Appointments

2016: CRUK Clinician Scientist and Senior Clinical Lecturer in Uro-Oncology, University of Glasgow
2016: Honorary Consultant Urological & Robotic Surgeon, NHS Greater Glasgow & Clyde
2015: Robotic Uro-Oncology Fellow, University College Hospital London
2011-2015: Higher Surgical Trainee (Urology), West of Scotland Deanery
2011-2015: Clinical Lecturer in Urology, University of Glasgow
2007-2011: Clinical Training Fellow, CRUK Beatson Institute/University of Glasgow
2006-2007: Senior House Officer, Urology, Southern General Hospital, Glasgow
2004-2006: Basic Surgical Trainee (General Surgery, Orthopaedics & Trauma, Cardiothoracic Surgery and Urology), West of Scotland Deanery
2003-2004: Pre-Registration House Officer (General Surgery/General Medicine), Glasgow Royal Infirmary, Glasgow

Honours and awards

ARTP Award 2014 (L'Association pour la Recherche sur les Tumeurs de la Prostate), 2014
Thomas and Margaret Smellie Prize (Best PhD thesis by a medical graduate), University of Glasgow, 2013
Hunterian Professorship, Royal College of Surgeons of England, 2013
EAU Prostate Cancer Research Award, 2013
The Royal Medico-Chirurgical Society of Glasgow Prize, 2012
Sir James Black Medal, Scottish Society of Experimental Medicine, 2011

Recent Publications

2016

Ahmad I, Mui E, Galbraith L, Patel R, Tan EH, Salji M, Rust AG, Repiscak P, Hedley A, Markert E, Loveridge C, van der Weyden L, Edwards J, Sansom OJ, Adams DJ, Leung HY. Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer. Proc Natl Acad Sci USA 113: 8290-5, 2016

2014

Choudhury Y, Yang Z, Ahmad I, Salt I, Leung HY. "AMP-activated kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer". Oncoscience 1(6): 446-456, 2014

Foth M, Ahmad I, van Rhijn BWG, van der Kwast T, Bergman AM, King, Louise, Ridgway R, Leung HY, Fraser S, Sansom OJ, Iwata T. "Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice". J Pathol 233: 148-158, 2014

Rajan P, Sudbery IM, Villasevil MEM, Mui E, Fleming J, Davis M, Ahmad I, Edwards J, Sansom OJ, Sims D, Ponting CP, Heger A, McMenemin RM, Pedley ID, Leung HY. "Next-generation Sequencing of Advanced Prostate Cancer Treated with Androgen-deprivation Therapy". European Urology 66(1): 32-9, 2014

Stockley J, Vilasevil ME, Nixon C, Ahmad I, Leung HY, Rajan P. "The RNA-binding protein hnRNPA2 regulates β-Catenin protein expression and is overexpressed in prostate cancer". RNA Biology 11(6): 755-765, 2014

Ahmad I, Crosbie RA, Ramsay AK, Nalagatla SK. "Comparison of Urologist and Radiologist gained Percutaneous Renal Access during PCNL: A Review". Journal of Clinical Urology 7: 20-24, 2104

2013

Ahmad I, Kalna G, Ismail M, Birrell F, Asterling S, McCartney E, Greene D, Davies J, Leung HY. "Prostate Gland Lengths and Iceball Dimensions Predict Micturition Functional Outcome Following Salvage Prostate Cryotherapy in Men with Radiation Recurrent Prostate Cancer". PLOS One 2013; 10.1371/journal.pone.0069243

Zhang T, Watson DG, Wang L, Abbas M, Murdoch L, Bashford L, Ahmad I, Lam NY, Ng ACF, Leung HY. "Application of Holistic Liquid Chromatography-High Resolution Mass Spectrometry Based Urinary Metabolomics for Prostate Cancer Detection and Biomarker Discovery". PLOS One 2013; 10.1371/journal.pone.0065880.

Patel R, Gao M, Ahmad I, Fleming J, Norman J, Sansom OJ, McKie AB, Singh LB, Seywright M, Barnetson RJ, Edwards J, Leung HY. "Sprouty2 expression governs prostate cancer progression by regulating cellular distribution of PTEN". Journal of Clinical Investigation 123(3): 1157-75, 2013

Ahmad I, Singh LB, Yang ZH, Kalna G, Fisher G, Cooper C, Cuzick J, Berney DM, Møller H, Scardino P, Leung HY. "Mir143 expression inversely correlates with nuclear ERK5 immunoreactivity in clinical prostate cancer". British Journal of Cancer 108(1):149-54, 2013

Yang Z, Laird A, Monaghan A, Seywright M, Ahmad I, Leung HY. "Incidental seminal vesicle amyloidosis observed in diagnostic prostate biopsies-are routine investigations for systemic amyloidosis warranted?" Asian Journal of Andrology 15(1):149-51, 2013

2012

McCall P, Bennett L, Ahmad I, Mackenzie LM, Forbes IW, Leung HY, Sansom OJ, Orange C, Seywright M, Underwood MA, Edwards J. "NFκB signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression". British Journal of Cancer 107(9): 1554-63, 2012

Gao M, Patel R, Ahmad I, Fleming J, Norman J, Sansom OJ, Leung HY. "SPRY2 loss enhances ErbB trafficking and PI3K/AKT signaling to drive human and mouse prostate carcinogenesis". EMBO Molecular Medicine 4(8): 776-90, 2012

Ahmad I, Small DR, Krishna NS, Akhtar MN, Leung HY. "Prostate Cancer Incidence in Patients on 5α-Reductase Inhibitors for Lower Urinary Tract Symptoms: A 14 Year Retrospective Study". BJMSU 5(4): 179-83, 2012

Barry L, Ahmad I, Pokrovska T, Rajan P. "Current management options for the small renal mass in a solitary kidney". Scott Med J 57(3): 157-62, 2012

Ahmad I, Sansom OJ, Leung HY. "Exploring molecular genetics of bladder cancer: lessons learned from mouse models". Disease Models & Mechanisms 5(3): 323-32, 2012

Ahmad I, Iwata T, Leung HY. "Mechanisms of FGFR-mediated carcinogenesis". Biochimica Et BiophysicaI Acta - Molecular Cell Research 1823(4): 850-60, 2012

Lab Members

Post-doc

Laura Galbraith (CRUK)

Research

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Seminars

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Find out more about our seminars including our Distinguished Seminar Programme.

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