The Biology group provides a key interface with the existing biology infrastructure at the Beatson as well as the wider CR-UK biology and drug discovery groups. Assay development and implementation skills are critical. Primary screening during hit validation, Hits-to-Leads and Lead Optimisation as well as cellular assay screening during these phases is established. Further, in vitro DMPK assays suitable for simple screening formats (e.g. Cytochrome P450 assays, liver microsomal turnover) are set up in order to help drive projects forward. The Biology group also has a significant role in automated cell screening in collaboration with the Beatson core.