Medicinal Chemistry Senior Scientific Officer

Starting Salary £24776 - £41536, depending on experience


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We are looking for a talented and motivated Medicinal Chemist who will take a central role in our drug discovery projects. The ideal candidate should have extensive hands-on experience of synthetic organic chemistry and an understanding of medicinal chemistry design principles along with excellent problem solving skills. Our research laboratory is equipped with state of the art equipment including, NMR spectrometers to support medicinal chemistry (Bruker AVANCE NEO 400) and for fragment screening and protein NMR (Bruker AVANCE NEO 600 with a CryoProbe) work.

Playing an influential role in our drug discovery projects, you will work collaboratively with all teams (biophysicists, protein scientists, crystallographers, biologists and chemists) at the Beatson and wider CRUK network to help formulate innovative and forward thinking approaches towards tackling exciting and challenging drug target classes.

As a predominantly lab-based medicinal chemist the role requires you to develop and use your skills to design and synthesise molecules for our drug discovery projects, contributing significantly to the progression of our portfolio through to the clinic. The high quality compounds that you produce will be critical, helping teams form an understanding of both the mechanism of action of our molecules and the target biology.

In addition, you will contribute to the development of the medicinal chemistry discipline by identifying and driving improvements and innovations that advance drug discovery projects.

Education Requirements:

• Ph.D. in Organic Chemistry, Chemical Biology or Medicinal Chemistry and 3+ years of experience in the pharmaceutical, biotech or not-for-profit drug discovery setting; or, an MSc/BSc in Chemistry, Chemical Biology or Medicinal Chemistry and 5+ years of experience in the pharmaceutical, biotech or not-for-profit drug discovery setting.

Skills & Experience:

• Demonstrable expertise in the practical and theoretical aspects of synthetic chemistry, with experience in synthesis, purification and analytical characterisation (LCMS & NMR)
• Up to date knowledge of the chemical literature
• Knowledge of medicinal chemistry design principles and the influence of physicochemical properties
• The use of structure-based design techniques and the influence of biophysical data
• An understanding of related drug discovery disciplines (biophysics, structural biology, pharmacology, ADME, formulation, drug safety/toxicology, IP)
• Dynamic personality with a passion for innovation and problem-solving
• Excellent communication with a collaborative approach to science, including experience of working as part of a multidisciplinary team.

In return, we offer an inspiring, supportive and multi-disciplinary environment in a state-of-the-art, purpose built laboratory in which to further enhance your skills and knowledge of medicinal chemistry, structural sciences, biophysics, cancer biology and drug discovery; providing you the opportunity to make a real difference to the lives of cancer patients.

Informal enquiries are welcome and should be addressed to Dr Justin Bower; (Joint Head of Beatson Drug Discovery Unit)

Closing date for applications is 9th August, 2019.

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