20th March 2019
The Beatson Institute would like to extend a warm welcome to Dr Crispin Miller, who has just started as our Head of Bioinformatics. Crispin joins us from Manchester, where he was senior group leader of the RNA Biology group at the Cancer Research UK Manchester Institute.
Crispin's research is focused on how gene expression is regulated within cells, and how these regulatory systems are altered in cancer. This has led to a long-term interest in noncoding RNAs, and their role in the cellular response to changing oxygen levels. Crispin’s background was originally in Computer Science and AI. His programme is centred on the use of computational techniques to explore high volumes of genomics data, and to use these approaches to identify patterns that help better understand the changes that drive tumour progression.
Crispin has said 'It’s been fantastic to move to Glasgow and to join the Beatson Institute. We’re already starting building new multidisciplinary collaborations and it’s a wonderfully stimulating environment to become a part of.'
23rd January 2019
Beatson researchers are set to receive almost £1.8 million over the next five years as part of a £19 million investment in a global project to investigate why some cancers are specific to certain tissues and not others.
Cancer Research UK's Grand Challenge is the most ambitious cancer research grant in the world, with the potential to revolutionise how we understand, prevent, diagnose and treat the disease.
The Beatson scientists will work as part of a team of researchers from Manchester, the US and the Netherlands who beat stiff international competition to secure the funding.
They will bring their world-leading expertise in bowel cancer to the pioneering project, which was selected by an international panel of experts from a shortlist of ten exceptional, multi-disciplinary collaborations from universities, institutes and industry across the globe.
Beatson Institute Director Owen Sansom said: “This Cancer Research UK Grand Challenge funding will be transformative. It will allow us to work together with some of the best research groups from around the world and to do some really exciting and ambitious research to try and find an answer to this key question about early disease in cancer.”
Cancer Research UK’s Grand Challenge was established to help scientists attack some of the hardest, unanswered questions in cancer research.
The international project team is looking to understand why genetic faults only affect certain tissues.
If someone carries a potentially cancer-causing gene mutation, this fault can exist in every cell of the body, but only causes specific cancers, such as breast or skin. The team is studying why this is the case, and will use this information to find ways to prevent or treat cancer in these organs.
Owen continued: “My team have been trying to understand for a number of years why mutations in a gene called APC are really common in bowel cancer. With this £1.8 million funding we will try to uncover why we only see the APC mutation in bowel cancer; why not breast cancer or skin cancer? If we can work out the reason this gene mutation doesn’t cause cancer in these other organs, then our hope is we might be able to find a way to make the bowel resistant to the APC mutation and prevent cancer from developing.”
The funding announcement has been covered by numerous media outlets.
For more information, visit www.cruk.org.uk/grandchallenge
Pictured above: Beatson Institute Director Owen Sansom (photo credit: Steve Welsh)
7th January 2019
Beatson Institute researchers led by Dr Saverio Tardito have been investigating the difference that using traditional media vs a homemade one that more closely mimics physiological conditions can make to the outcome of experiments. The work has been published in Science Advances: Improving the metabolic fidelity of cancer models with a physiological cell culture medium. The research was covered in an excellent article written by Ed Yong at The Atlantic: Scientists Have Been Studying Cancers in a Very Strange Way for Decades
Click here to read more about Saverio's research group.
27th November 2018
Researchers at the Institute of Cancer Sciences, University of Glasgow have published a study looking at how the intestine coordinates a multi-organ programme which is essential to achieve a balance between the use and storing of body energy in response to food.
When nutrients such as sugars and fats are absorbed in the gut, any excess nutrients are stored away in the body as energy reserves, for example, in adipose (fat) tissue and the liver. These energy reserves can then be used as backup when food is scarce, and the body has mechanisms for mobilising these backup nutrients. However, in order for the body to use these resources efficiently, it’s important for it to be able to recognise when these reserves should be used and when they shouldn’t.
In this study in fruit flies, published in Cell Metabolism, researchers found that when there is food in the gut, the gut releases a hormone that acts on neurons in the central nervous system (CNS), which in turn tunes down signals to the energy reserve tissues to indicate such reserves are not needed. In contrast, under starvation conditions, the gut does not release this hormone, which then allows the CNS to turn up the activity of these neurons to allow mobilisation of energy reserves.
Therefore, flies lacking the nutrient-sensing hormone released by the gut showed uncontrolled use of energy reserves, and as a result these flies are not able to build up sufficient reserves to allow them to cope with periods of hunger. Interestingly, the human version of one of the proteins involved in this pathway has previously been associated with obesity, through an unknown mechanism.
These findings highlight the long-reaching impact of intestinal function to organismal health and disease. Important implications of this work include intestinal pathologies such as colorectal cancer, as it may explain the origin and mechanisms of metabolic disorders and disruption of multiple CNS-controlled body functions, including sleep and feeding, often observed in cancer patients.
Scopelliti A, Bauer C, Yu Y, Zhang T, Kruspig B, Murphy DJ, Vidal M, Maddocks ODK, Cordero JB. A Neuronal Relay Mediates a Nutrient Responsive Gut/Fat Body Axis Regulating Energy Homeostasis in Adult Drosophila. Cell Metab 2018. doi: 10.1016/j.cmet.2018.09.021
22nd November 2018
Beatson Institute scientists have found that mannose sugar, a nutritional supplement, can both slow tumour growth and enhance the effects of chemotherapy in mice with multiple types of cancer. Click here to read the press release from CRUK.
The results of the study, which was led by Professor Kevin Ryan, have been published in Nature.
The study has been covered by the BBC and other news outlets. Click here to read the BBC articles: Simple sugar supplement 'can slow cancer growth' and Sugary supplement mannose could help fight cancer
Click here to read more about Professor Ryan's research group.