21st June 2018
Dr Daniel Murphy and others at the Institute have published findings in Science Translational Medicine showing that a treatment that is already approved in certain types of cancer could also be used in another type of lung cancer (KRAS-driven lung cancer) for which there is currently no specific treatment. The fact that it is already approved for use in other cancers means that it could be available for patients with KRAS-driven lung cancer much sooner than it otherwise would be.
Daniel said 'There is a pressing need to develop alternative strategies for more effective treatment of KRAS‐driven lung cancer, and this is a promising breakthrough which we hope could benefit patients soon.
'The inhibitor we studied – a multi-ERBB inhibitor – helped sensitise tumours and was of therapeutic benefit when used in combination with another cancer drug called Trametinib, resulting in a clear extension of lifespan.
'Based on our findings, we hope lung cancer patients with the KRAS-driven form of lung cancer may in future benefit from inclusion of this inhibitor in their treatment plan.'
We were delighted to welcome new senior group leader Martin Bushell and his team to the Institute this month. Martin and his group are studying the fundamental processes underlying protein synthesis in cells and how these are altered in tumours. A better understanding of how these processes work could lead to new treatments for cancer.
More details of Martin's research can be found here.
Congratualtions to Dr Nathiya Mathalagu from the Beatson Institute who is amongst the five winners of this year's prestigious L'Oréal UNESCO For Women In Science Awards. For the past 11 years, L'Oréal UKI and UNESCO UK have awarded five Fellowships worth £15,000 each to early career researchers. The Fellowships are designed to provide flexible and practical financial support for the winners to further their research and careers and provide support to keep them in the scientific community. With the flexible grant, winners may choose to spend their fellowship on buying scientific equipment, paying for childcare costs, travel costs or indeed whatever they need to continue their research.
Nathiya seeks to understand the processes that drive tumour development and how the immune system can be harnessed for more effective anti-cancer therapy or prevention – particularly in pancreatic tumours. With a one-year old, the L'Oréal UNESCO funding will cover part of her childcare costs. Nathiya currently uses her annual leave to take one day off a week. Covering her childcare costs will increase the time she can spend in the lab and her productivity.
More details of the L'Oréal UNESCO For Women In Science international programme can be found here.
Nathiya (second from left) and her fellow awardees
At the Cancer Research UK Beatson Institute we are committed to promoting good practice in research by all our researchers. This perspective article in Nature outlines the approach we have taken, which has included creating a research integrity adviser role, described in the article, as well as providing the best training, advice and support for our scientists: https://www.nature.com/articles/d41586-018-05140-x, "Give every paper a read for reproducibility"
25th April, 2018
The Institute's Dr Tom Bird appeared on Reporting Scotland to discuss the issue of liver cancer and obesity: https://www.youtube.com/watch?v=eOJhh61GwgE
Tom is a group leader here at the Beatson Institute and is also an Honorary Consultant Hepatologist at the Royal Infirmary of Edinburgh. For a description of Tom's research on liver disease and regeneration, click here.
Today (27th March 2018), the Institute publishes its Gender Pay Gap report for 2017, ahead of the Government deadline of 4th April 2018.
In this report, you will find:
• A summary of our gender pay gap
• A summary of our challenges, which contribute to our pay gap
• Our commitments and actions to narrowing our gender pay gap