It is with the deepest regret that we have to announce the death of our dear friend and colleague Professor Marcos Vidal.
CRUK's annual research publication Pioneering Research 2014/15 can be viewed here: www.cruk.org/pioneering-research. This includes articles on metabolomics and drug discovery featuring Eyal Gottlieb, Jurre Kamhorst and Martin Drysdale from the Beatson.
The Prostate Cancer Foundation (PCF) in the US has recently awarded Prof Hing Leung, head of our Prostate Cancer Biology Laboratory at the CRUK Beatson Institute, a $1M Challenge Award. His project 'Optimizing the Use of Taxane Chemotherapy in Prostate Cancer' will study patients treated with chemotherapy in order to identify biomarkers that can predict which patients will most benefit from chemotherapy, and to identify mechanisms of chemotherapy resistance.
Beatson researchers Karen Blyth and Kirsteen Campbell have been awarded a Breast Cancer Campaign pilot grant to investigate the role of MCL-1 and MYC in triple-negative breast cancer.
More details can be found here:
Professor Laura Machesky's work identifying Fascin as a potential key player in how pancreatic cancer develops has been featured on Cancer Research UK's Science Blog as one of the charity's highlights of 2014.
Dave Bryant, who recently joined the Institute as a Beatson Associate, has a new paper in Developmental Cell that describes some of the work he was doing while in the USA and which will form the basis of his research programme here.
Dave and his co-authors describe how signals coming from the extracellular matrix (ECM) regulate the polarisation of cells within epithelial tissues, allowing them to orient their apical surfaces correctly and thus form a lumen. Competing RhoA and PKC signalling pathways play key roles in this process. Strikingly, perturbation of these ECM-directed pathways switches epithelial cells towards forming front-rear polarised, and multicellular, invasive cell aggregates. These findings may well have important implications in cancer as switching from lumen-containing tissues to invasive cell aggregates is a hallmark of epithelial cancers. Dave's lab will be investigating this further, in particular in prostate cancer.
Link to Dave's lab page
Bryant DM, Roignot J, Datta A, Overeem AW, Kim M, Yu W, Peng X, Eastburn DJ, Ewald AJ, Werb Z, Mostov KE. A molecular switch for the orientation of epithelial cell polarization. Dev Cell, Epub 9 Oct 2014 DOI: http://dx.doi.org/10.1016/j.devcel.2014.08.027