Recent publications

September 2018

The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.
Stephen LA, ElMaghloob Y, McIlwraith MJ, Yelland T, Castro Sanchez P, Roda-Navarro P, Ismail S. Dev Cell 2018. doi: 10.1016/j.devcel.2018.08.012

August 2018

TGFbeta inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.
Bird TG, Muller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, et al. Sci Transl Med 2018; 10 (454). doi: 10.1126/scitranslmed.aan1230

Identifying Target RNAs of PARPs.
Bock FJ, Chang P. Methods Mol Biol 2018; 1813: 327-41. doi: 10.1007/978-1-4939-8588-3_23

July 2018

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis.
Riley JS, Quarato G, Cloix C, Lopez J, O'Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW. EMBO J. 2018 Jul 26. pii: e99238. doi: 10.15252/embj.201899238.

Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.
Morris HT, Fort L, Spence HJ, Patel R, Vincent DF, Park JH, Snapper SB, Carey FA, Sansom OJ, Machesky LM. J Pathol 2018; 245: 337-48 doi: 10.1002/path.5086

FGFR3 mutation increases bladder tumorigenesis by suppressing acute inflammation.
Foth M, Ismail NFB, Kung JSC, Tomlinson D, Knowles MA, Eriksson P, Sjodahl G, Salmond JM, Sansom OJ, Iwata T. J Pathol 2018 doi: 10.1002/path.5143

June 2018

Structure specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones.
Marcianò G, Da Vela S, Tria G, Svergun DI, Byron O, Huang DT. J Biol Chem. 2018 Jun 29; pii: jbc.RA117.000994. doi: 10.1074/jbc.RA117.000994

Harnessing synthetic lethality to predict the response to cancer treatment.
Lee JS, Das A, Jerby-Arnon L, Arafeh R, Auslander N, Davidson M, McGarry L, James D, Amzallag A, Park SG, Cheng K, Robinson W, Atias D, Stossel C, Buzhor E, et al. Nat Commun 2018;9(1):2546. doi: 10.1038/s41467-018-04647-1

The ERBB network facilitates KRAS-driven lung tumorigenesis
Kruspig B, Monteverde T, Neidler S, Hock A, Kerr E, Nixon C, Clark W, Hedley A, Laing S, Coffelt SB, Le Quesne J, Dick C, Vousden K, Martins CP, Murphy DJ.
Sci Transl Med. 2018 Jun 20; 10 (446). pii: eaao2565. doi: 10.1126/scitranslmed.aao2565.
Click here to read the full text.

Intestinal Stem Cell Dynamics: A Story of Mice and Humans
Hodder MC, Flanagan DJ, Sansom OJ.
Cell Stem Cell. 2018 Jun 1;22(6):785-787. doi: 10.1016/j.stem.2018.05.005.
Click here to read the full text.

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.
Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA. Cancer Discov 2018; 8: 764-79 doi: 10.1158/2159-8290.CD-17-0867

May 2018

Is oxidative stress MYC's Achilles heel?
Muthalagu N, Murphy DJ.
Cell Death Differ. 2018 May 29. doi: 10.1038/s41418-018-0117-4. [Epub ahead of print]
Click here to read the full text.

MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus
Godfrey JD, Morton JP, Wilczynska A, Sansom OJ, Bushell MD.
Cell Death Dis. 2018 May 29;9(6):644. doi: 10.1038/s41419-018-0628-4.
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A physical model of cell metabolism
Fernandez-de-Cossio-Diaz J, Vazquez A.
Sci Rep. 2018 May 29;8(1):8349. doi: 10.1038/s41598-018-26724-7.
Click here to read the full text.

Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.
Morris HT, Fort L, Spence HJ, Patel R, Vincent DF, Park JH, Snapper SB, Carey FA, Sansom OJ, Machesky LM. J Pathol 2018; 245: 337-48 doi: 10.1002/path.5086
Click here to read the full text.

STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.
Woroniuk A, Porter A, White G, Newman DT, Diamantopoulou Z, Waring T, Rooney C, Strathdee D, Marston DJ, Hahn KM, Sansom OJ, Zech T, Malliri A. Nat Commun 2018; 9: 2124 doi: 10.1038/s41467-018-04404-4

Lenvatinib and its use in the treatment of unresectable hepatocellular carcinoma
Baxter MA, Glen H, Evans TR.
Future Oncol. 2018 May 22. doi: 10.2217/fon-2017-0689. [Epub ahead of print]
Click here to view in PubMed.

Targeting BCL-2 regulated apoptosis in cancer
Campbell KJ, Tait SWG.
Open Biol. 2018 May;8(5). pii: 180002. doi: 10.1098/rsob.180002. Review.
Click here to read full text.

Structure specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones
Marcianò G, Da Vela S, Tria G, Svergun DI, Byron O, Huang DT.
J Biol Chem. 2018 May 15. pii: jbc.RA117.000994. doi: 10.1074/jbc.RA117.000994. [Epub ahead of print]
Click here to read full text.

Research

At the bench 3 160

Read more about the Research Groups working at the Beatson Institute.

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Seminars

Running a gel 154

Find out more about our seminars including our Distinguished Seminar Programme.

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