Recent publications

January 2019

Lopez J, Tait SWG. Application of Mito-Priming to Generate BCL-2 Addicted Cells. Methods in molecular biology (Clifton, NJ) 2019;1877:45-60. doi: 10.1007/978-1-4939-8861-7_3

Vande Voorde J, Ackermann T, Pfetzer N, Sumpton D, Mackay G, Kalna G, Nixon C, Blyth K, Gottlieb E, Tardito S. Improving the metabolic fidelity of cancer models with a physiological cell culture medium. Science Advances 2019; 5: eaau7314

November 2018

Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels.
Novo D, Heath N, Mitchell L, Caligiuri G, MacFarlane A, Reijmer D, Charlton L, Knight J, Calka M, McGhee E, Dornier E, Sumpton D, Mason S, Echard A, Klinkert K, et al. Nat Commun 2018; 9: 5069. doi: 10.1038/s41467-018-07339-y

Mannose impairs tumour growth and enhances chemotherapy.
Gonzalez PS, O'Prey J, Cardaci S, Barthet VJA, Sakamaki JI, Beaumatin F, Roseweir A, Gay DM, Mackay G, Malviya G, Kania E, Ritchie S, Baudot AD, Zunino B, Mrowinska A, et al. Nature 2018; 563: 719-23. doi: 10.1038/s41586-018-0729-3

The phospholipid PI(3,4)P2 is an apical identity determinant.
Roman-Fernandez A, Roignot J, Sandilands E, Nacke M, Mansour MA, McGarry L, Shanks E, Mostov KE, Bryant DM. Nat Commun 2018; 9: 5041. doi: 10.1038/s41467-018-07464-8

October 2018

Analysis of cell proliferation and tissue remodelling uncovers a KLF4 activity score associated with poor prognosis in colorectal cancer.
Halim S, Markert EK, Vazquez A. Br J Cancer 2018. doi: 10.1038/s41416-018-0253-0

September 2018

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.
Alkanderi S, Molinari E, Shaheen R, Elmaghloob Y, Stephen LA, Sammut V, Ramsbottom SA, Srivastava S, Cairns G, Edwards N, Rice SJ, Ewida N, Alhashem A, White K, Miles CG, Steel DH, Alkuraya FS, Ismail S, Sayer JA. Am J Hum Genet 2018; 103(4): 612-20. doi: 10.1016/j.ajhg.2018.08.015

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.
Fort L, Batista JM, Thomason PA, Spence HJ, Whitelaw JA, Tweedy L, Greaves J, Martin KJ, Anderson KI, Brown P, Lilla S, Neilson MP, Tafelmeyer P, Zanivan S, Ismail S, Bryant DM, Tomkinson NCO, Chamberlain LH, Mastick GS, Insall RH, Machesky LM. Nat Cell Biol. 2018 Oct; 20(10): 1159-71. doi: 10.1038/s41556-018-0198-9

Single-Turnover RING/U-Box E3-Mediated Lysine Discharge Assays.
Buetow L, Gabrielsen M, Huang DT. Methods Mol Biol 2018; 1844: 19-31. doi: 10.1007/978-1-4939-8706-1_2

The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.
Stephen LA, ElMaghloob Y, McIlwraith MJ, Yelland T, Castro Sanchez P, Roda-Navarro P, Ismail S. Dev Cell 2018. doi: 10.1016/j.devcel.2018.08.012

August 2018

TGFbeta inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.
Bird TG, Muller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, et al. Sci Transl Med 2018; 10 (454). doi: 10.1126/scitranslmed.aan1230 F1000

Identifying Target RNAs of PARPs.
Bock FJ, Chang P. Methods Mol Biol 2018; 1813: 327-41. doi: 10.1007/978-1-4939-8588-3_23

July 2018

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis.
Riley JS, Quarato G, Cloix C, Lopez J, O'Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW. EMBO J. 2018 Jul 26. pii: e99238. doi: 10.15252/embj.201899238.

Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.
Morris HT, Fort L, Spence HJ, Patel R, Vincent DF, Park JH, Snapper SB, Carey FA, Sansom OJ, Machesky LM. J Pathol 2018; 245: 337-48 doi: 10.1002/path.5086

FGFR3 mutation increases bladder tumorigenesis by suppressing acute inflammation.
Foth M, Ismail NFB, Kung JSC, Tomlinson D, Knowles MA, Eriksson P, Sjodahl G, Salmond JM, Sansom OJ, Iwata T. J Pathol 2018 doi: 10.1002/path.5143

 

Research

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Seminars

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Find out more about our seminars including our Distinguished Seminar Programme.

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