Recent publications

October 2018

Analysis of cell proliferation and tissue remodelling uncovers a KLF4 activity score associated with poor prognosis in colorectal cancer.
Halim S, Markert EK, Vazquez A. Br J Cancer 2018. doi: 10.1038/s41416-018-0253-0

September 2018

ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.
Alkanderi S, Molinari E, Shaheen R, Elmaghloob Y, Stephen LA, Sammut V, Ramsbottom SA, Srivastava S, Cairns G, Edwards N, Rice SJ, Ewida N, Alhashem A, White K, Miles CG, Steel DH, Alkuraya FS, Ismail S, Sayer JA. Am J Hum Genet 2018; 103(4): 612-20. doi: 10.1016/j.ajhg.2018.08.015

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.
Fort L, Batista JM, Thomason PA, Spence HJ, Whitelaw JA, Tweedy L, Greaves J, Martin KJ, Anderson KI, Brown P, Lilla S, Neilson MP, Tafelmeyer P, Zanivan S, Ismail S, Bryant DM, Tomkinson NCO, Chamberlain LH, Mastick GS, Insall RH, Machesky LM. Nat Cell Biol. 2018 Oct; 20(10): 1159-71. doi: 10.1038/s41556-018-0198-9

Single-Turnover RING/U-Box E3-Mediated Lysine Discharge Assays.
Buetow L, Gabrielsen M, Huang DT. Methods Mol Biol 2018; 1844: 19-31. doi: 10.1007/978-1-4939-8706-1_2

The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.
Stephen LA, ElMaghloob Y, McIlwraith MJ, Yelland T, Castro Sanchez P, Roda-Navarro P, Ismail S. Dev Cell 2018. doi: 10.1016/j.devcel.2018.08.012

August 2018

TGFbeta inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.
Bird TG, Muller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, et al. Sci Transl Med 2018; 10 (454). doi: 10.1126/scitranslmed.aan1230

Identifying Target RNAs of PARPs.
Bock FJ, Chang P. Methods Mol Biol 2018; 1813: 327-41. doi: 10.1007/978-1-4939-8588-3_23

July 2018

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis.
Riley JS, Quarato G, Cloix C, Lopez J, O'Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW. EMBO J. 2018 Jul 26. pii: e99238. doi: 10.15252/embj.201899238.

Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.
Morris HT, Fort L, Spence HJ, Patel R, Vincent DF, Park JH, Snapper SB, Carey FA, Sansom OJ, Machesky LM. J Pathol 2018; 245: 337-48 doi: 10.1002/path.5086

FGFR3 mutation increases bladder tumorigenesis by suppressing acute inflammation.
Foth M, Ismail NFB, Kung JSC, Tomlinson D, Knowles MA, Eriksson P, Sjodahl G, Salmond JM, Sansom OJ, Iwata T. J Pathol 2018 doi: 10.1002/path.5143

June 2018

Structure specific recognition protein-1 (SSRP1) is an elongated homodimer that binds histones.
Marcianò G, Da Vela S, Tria G, Svergun DI, Byron O, Huang DT. J Biol Chem. 2018 Jun 29; pii: jbc.RA117.000994. doi: 10.1074/jbc.RA117.000994

Harnessing synthetic lethality to predict the response to cancer treatment.
Lee JS, Das A, Jerby-Arnon L, Arafeh R, Auslander N, Davidson M, McGarry L, James D, Amzallag A, Park SG, Cheng K, Robinson W, Atias D, Stossel C, Buzhor E, et al. Nat Commun 2018;9(1):2546. doi: 10.1038/s41467-018-04647-1

The ERBB network facilitates KRAS-driven lung tumorigenesis
Kruspig B, Monteverde T, Neidler S, Hock A, Kerr E, Nixon C, Clark W, Hedley A, Laing S, Coffelt SB, Le Quesne J, Dick C, Vousden K, Martins CP, Murphy DJ.
Sci Transl Med. 2018 Jun 20; 10 (446). pii: eaao2565. doi: 10.1126/scitranslmed.aao2565.
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Intestinal Stem Cell Dynamics: A Story of Mice and Humans
Hodder MC, Flanagan DJ, Sansom OJ.
Cell Stem Cell. 2018 Jun 1;22(6):785-787. doi: 10.1016/j.stem.2018.05.005.
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Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.
Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA. Cancer Discov 2018; 8: 764-79 doi: 10.1158/2159-8290.CD-17-0867

 

Research

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Read more about the Research Groups working at the Beatson Institute.

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Seminars

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Find out more about our seminars including our Distinguished Seminar Programme.

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