Metastasis, recurrence and the cancer microenvironment

Prof Laua Machesky

Starting Salary from £31,604 to £41,929 (Depending on experience) plus relocation allowance where appropriate.

Initial 3 year fixed term contract (with possibility of up to 2 year extension)


The migration, invasion and metastasis group explore the mechanisms behind cancer metastasis and recurrence. We are particularly interested in how actin cytoskeletal dynamics contribute to mechanosensing and how the extracellular matrix and tumour microenvironment affect disseminated cancer cells. We collaborate with physicists and engineers to use a multidisciplinary approach to study cell migration and invasion in a 3D environment. We also use advanced imaging methods such as optogenetics and FRET-FLIM to determine how cells communicate and signal in complex environments. The successful candidate will have the opportunity to be a part of a multidisciplinary team involved in design and use of advanced imaging microscopes for study of the metastatic niche.

Applicants must have a PhD in a relevant field, be ambitious and driven by scientific curiosity. Skills with advanced microscopy, quantitative cell biology, image analysis and molecular biology would be an advantage. A knowledge of or interest in cancer metastasis and the microenvironment is essential. Training will be provided in all areas.

To find out more about this unique opportunity to establish advanced skills and expertise in this exciting field please contact: Professor Laura Machesky

The Cancer Research UK Beatson Institute is committed to increase the number of female scientists at this level and encourages female applicants to apply. We have recently introduced a highly attractive maternity policy which provides 12-18 months support and funding for postdocs wishing to take time off to spend with their children.

Closing date for applications is 24 June 2019



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