Introduction
 As a result of increased bioenergetic demands and the need to grow and proliferate faster, cancer cells have unique metabolic traits compared to normal cells.
At the same time, cancer cells are exposed to more extreme conditions of metabolic stress due to the uncontrolled growth of the tumour away from the vascular system that provides oxygen and nutrients to its cells. Therefore, cancer cells have developed defence mechanisms that are selected under conditions of stress and cells that survive this strongly selective environment have a more aggressive phenotype.
Targeting these survival mechanisms may help eliminate cancer growth and specifically induce cancer cell death.
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Lab Report
 Link to Gottlieb Scientific Report 2008 141.97 Kb
Key PublicationsGonzalvez F, Schug ZT, Houtkooper RH, MacKenzie ED, Brooks DG, Wanders RJ, Petit PX, Vaz FM, Gottlieb E (2008). Cardiolipin provides an essential activating platform for caspase-8 on mitochondria. J Cell Biol. 183, 681-96.
MacKenzie ED, Selak MA, Tennant DA, Payne LJ, Crosby S, Frederiksen CM, Watson DG, Gottlieb E. (2007). Cell-permeating α-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol. Cell. Biol. 27, 3282-3289.
Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nadano K, Bartrons R, Gottlieb E, Vousden, KH. (2006). TIGAR, a novel regulator of glycolysis and apoptosis, is induced by p53. Cell 126, 107-120.
Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, Yi P, Simon MC, Thompson CB, Gottlieb E (2005). Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase. Cancer Cell 7, 77-85.
Gottlieb E, Tomlinson IPM (2005). Mitochondrial tumour suppressors: a genetic and biochemical update. Nature Rev. Cancer 5, 857-866.
Biography
Education and qualifications
1999: PhD, Weizmann Institute of Science, Israel, Supervisor Moshe Oren
1992: MSc, Weizmann Institute of Science, Israel, Supervisor Moshe Oren
1990: BSc, Hebrew University, Israel
Appointments
2007-present: Reader, University of Glasgow
2003-present: Group Leader, Beatson Institute for Cancer Research, Glasgow
1999-2003: Postdoctoral Fellow with Craig Thompson, University of Pennsylvania, Philadelphia, USA
1998-1999: Postdoctoral Fellow with Craig Thompson, University of Chicago, USA
Honours and awards
Leukemia and Lymphoma Society Special Fellowship, 2001
EMBO Long-Term Fellowship, 1998
Recent Publications
Boulahbel H, Duran RV, Gottlieb E (2009). Prolyl hydroxylases as regulators of cell metabolism. Biochem Soc Trans. 37, 291-4.
Frezza C, Gottlieb E (2009). Mitochondria in cancer: Not just innocent bystanders. Semin Cancer Biol., Published online 3 December 2008. doi:10.1016/j.semcancer.2008.11.008
Gonzalvez F, Schug ZT, Houtkooper RH, MacKenzie ED, Brooks DG, Wanders RJ, Petit PX, Vaz FM, Gottlieb E (2008). Cardiolipin provides an essential activating platform for caspase-8 on mitochondria. J Cell Biol. 183, 681-96.
Gonzalvez F, Gottlieb (2007). Cardiolipin: setting the beat of apoptosis. Apoptosis 12, 877-885.
MacKenzie ED, Selak MA, Tennant DA, Payne LJ, Crosby S, Frederiksen CM, Watson DG, Gottlieb E. (2007). Cell-permeating α-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol. Cell. Biol. 27, 3282-3289.
Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nadano K, Bartrons R, Gottlieb E, Vousden, KH. (2006). TIGAR, a novel regulator of glycolysis and apoptosis, is induced by p53. Cell 126, 107-120.
Gottlieb E. (2006). OPA1 and PARL keep a lid on apoptosis. Cell 126, 27-29.
King A, Selak MA, Gottlieb E. (2006). Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Oncogene 25, 4675-4682.
Selak MA, Duran-Diaz R, Gottlieb E. (2006). Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells. Biochimica Biophysica Acta 1757, 567-572.
Videos and Images
Gottlieb lab members (from left): Raul Duran, Christian Frezza, Elaine MacKenzie, Dan Tennant, Eyal Gottlieb, Lisa Heiserich, Zach Schug
Studying mitochondrial structure using a scanning electron microscope. Mitochondria were purified by Francois Gonzalvez (a former student in the lab) and the image was taken by Prof. Terry Allen from the Paterson Institute for Cancer Research in Manchester.
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