Introduction
 Introduction TGF-β is a pleiotropic cytokine that can act as both a tumour suppressor and a tumour promoter in a context dependent manner. It induces growth arrest and apoptosis in normal epithelia, however during their development solid tumours frequently modulate their response to TGF-β and utilise this cytokine as a promoter of motility, survival, invasion, vascularisation, metastasis and/or immunosuppression.
We are studying the spatial, temporal and tissue specific regulation of TGF-β signal transduction pathways to understand how TGF-β acts as a tumour suppressor and a tumour promoter. Our ultimate goals are to develop therapeutics that selectively target the pro-oncogenic actions of TGF-β whilst maintaining its important normal physiological functions, and to identify patient selection criteria for the use of these therapeutics.
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Lab Report
 Link to Inman Scientific Report 2008 156.87 Kb
Key PublicationsSpender LC, O’Brien DI, Simpson D, Dutt D, Gregory CD, Allday Mj, Clark LJ, Inman GJ. TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL. Cell Death and Differentiation, Published online 9 January 2009.
Fleming YM, Ferguson GJ, Spender LC, Larsson J, Karlsson S, Ozanne BW, Grosse R, Inman GJ. TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation. Oncogene, Published online 15 December 2008.
Spender LC, Inman GJ (2009). TGF-beta induces growth arrest in Burkitt's lymphoma cells via transcriptional repression of E2F-1. J Biol Chem.284, 1435-42.
Inman GJ. (2005). Linking Smads and transcriptional activation. Biochemical Journal 386, el-e3.
Biography
Education and qualifications
1995: PhD, University of London, Supervisor Paul Farrell
1990: BSc, Biology (First Class Honours), University of York
Appointments
2003-present: Group Leader and AICR Fellow, Beatson Institute for Cancer Research
2000-2003: Postdoctoral Fellow with Caroline Hill, CR-UK London Research Institute
1996-2000: Postdoctoral Fellow with Martin Allday, Ludwig Institute for Cancer Research, London
1995-1996: Postdoctoral Fellow with Ed Ziff, NYU Medical Center, New York, USA
Committee membership
2004-present: Tenovus Scotland
Recent Publications
Spender LC, O’Brien DI, Simpson D, Dutt D, Gregory CD, Allday Mj, Clark LJ, Inman GJ. TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL. Cell Death and Differentiation, Published online 9 January 2009.
Fleming YM, Ferguson GJ, Spender LC, Larsson J, Karlsson S, Ozanne BW, Grosse R, Inman GJ. TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation. Oncogene, Published online 15 December 2008.
Spender LC, Inman GJ (2009). TGF-beta induces growth arrest in Burkitt's lymphoma cells via transcriptional repression of E2F-1. J Biol Chem.284, 1435-42.
Frame MC, Inman GJ (2008). NCAM is at the heart of reciprocal regulation of E-cadherin- and integrin-mediatied adhesions via signaling modulation. Developmental Cell 15, 494-6.
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