Lab Report
Link to Ryan Scientific Report 2008 130.15 Kb
Key Publications
Wilkinson S, O'Prey J, Fricker M, Ryan KM (2009). Hypoxia-selective
macroautophagy and cell survival signaled by autocrine PDGFR activity.
Genes Dev 23, 1283-8.
O'Prey J, Skommer J, Wilkinson S, Ryan KM. Analysis of DRAM-related
proteins reveals evolutionarily conserved and divergent roles in the
control of autophagy. Cell Cycle 2009 Jul 19; 8(14). [Epub ahead of
print]
Bell HS, Ryan KM (2008). iASPP inhibition: increased options in
targeting the p53 family for cancer therapy. Cancer Res. 68, 4959-62.
Crighton D, O’Prey J, Bell HS, Ryan KM (2007). p73 regulates DRAM- independent autophagy that does not contribute to programmed cell death. Cell Death & Differ. 14, 1071-9.
Bell HS, Dufes C, O’Prey J, Crighton D, Bergamaschi D, Lu X, Schätzlein AG, Vousden KH, Ryan KM (2007). A novel p53-derived apoptotic peptide de-represses p73 to cause tumor regression in vivo. J Clin Invest. 117, 1008-18.
Crighton D, Wilkinson S, O’Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM (2006). DRAM – a p53- induced modulator of autophagy is critical for apoptosis. Cell 126, 121-34.
Biography
Education and qualifications
1996: PhD, Beatson Institute for Cancer Research (University of Glasgow), Supervisor George Birnie
1991: BSc, Biochemistry (Honours), University of Liverpool
Appointments
2007-present: Professor of Molecular Cell Biology, University of Glasgow
2007-present: Senior Group Leader, Beatson Institute for Cancer Research
2002-2008: Cancer Research UK Senior Cancer Research Fellow
2001-2007: Junior Group Leader, Beatson Institute for Cancer Research
1996-2001: Postdoctoral fellow with Karen Vousden, National Cancer Institute, Frederick, USA
Honours and awards
Certificate of Merit - European Association for Cancer Research ‘Young Cancer Researcher Award’, 2002
Cancer Research UK Senior Cancer Research Fellowship, 2001
National Institutes of Health Year 2001 Fellows Award for Research Excellence, 2000
National Institutes of Health Year 2000 Fellows Award for Research Excellence, 1999
Recent Publications
O'Prey J, Skommer J, Wilkinson S, Ryan KM. Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy. Cell Cycle 2009 Jul 19; 8(14). [Epub ahead of print]
Wilkinson S, O'Prey J, Fricker M, Ryan KM (2009). Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity. Genes Dev 23, 1283-8.
Martin AG, Trama J, Crighton D, Ryan KM, Fearnhead HO (2009). Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B. Aging 1, 335-49.
Yee KS, Wilkinson S, James J, Ryan KM, Vousden KH. PUMA- and Bax-induced autophagy contributes to apoptosis. Cell Death Differ. 2009 Mar 20. [Epub ahead of print]
O’Prey J, Wilkinson S, Ryan KM (2008). Tumor antigen LRRC15 impedes adenoviral infection – implications for viral based cancer therapy. J Virol. 82, 5933-9.
Park MA, Zhang G, Martin AP, Hamed H, Mitchell C, Hylemon PB, Graf M, Rahmani M, Ryan K, Liu X, Spiegel S, Norris J, Fisher PB, Grant S, Dent P (2008). Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. Cancer Biol Ther. 7, 1648-62.
Bell HS, Ryan KM (2008). iASPP inhibition: increased options in targeting the p53 family for cancer therapy. Cancer Res. 68, 4959-62.
Klionsky DJ
et al. (2008). Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4, 1-25.
Bell HS, Dufes C, O’Prey J, Crighton D, Bergamaschi D, Lu X, Schätzlein AG, Vousden KH, Ryan KM (2007). A novel p53-derived apoptotic peptide de-represses p73 to cause tumor regression in vivo. J Clin Invest. 117, 1008-18.
Crighton D, O’Prey J, Bell HS, Ryan KM (2007). p73 regulates DRAM- independent autophagy that does not contribute to programmed cell death. Cell Death & Differ. 14, 1071-9.
Bell HS, Ryan KM (2007). Targeting the p53 family for cancer therapy – ‘Big Brother’ joins the fight. Cell Cycle 6, 1995-2000.
Crighton D, Wilkinson S, Ryan KM (2007). DRAM links autophagy to p53 and programmed cell death. Autophagy 3, 72-4.
Ewings KE, Ryan KM (2007). Hzf and hCAS/CSE1L: making the right choice in p53-mediated tumour suppression. Cell Res. 17, 829-31.
Bell LA, O’Prey, Ryan KM (2006). DNA-binding independent cell death from a minimal pro-apoptotic region of E2F1. Oncogene 25, 2656-63.
Crighton D, Wilkinson S, O’Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM (2006). DRAM – a p53- induced modulator of autophagy is critical for apoptosis. Cell 126, 121-34.
The aim of our group is to understand the factors regulating programmed cell death in cancer cells. Since it is known that inhibition of cell death mechanisms is a common event in tumour development, this poses problems for many forms of chemotherapy that utilise cell death pathways, leading to drug resistance. 
