Link to Ozanne Scientific Report 2008 161.83 Kb

Key Publications

Spence HJ, McGarry L, Chew CS, Carragher NO, Scott-Carragher LA, Yuan Z, Croft DR, Olson MF, Frame M, Ozanne BW (2006). AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localisation and activity of nondifferentially expressed proteins. Mol Cell Biol. 26, 1480-95.

Scott LA, Vass JK, Parkinson EK, Gillespie DA, Winnie JN and Ozanne BW (2004). Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalisation, and the tumour suppressors p16INK4A and RB. Mol Cell Biol. 24, 1540-59.

Hennigan RF, Hawker KL and Ozanne BW (1994). Fos-transformation activates genes associated with invasion. Oncogene 12, 3591-600.

Education and qualifications
1975: PhD, New York University/Cold Spring Harbor Laboratory, Supervisor Joseph F. Sambrook
1969: BSc, Zoology, University of Wisconsin, Madison, USA

Appointments
1989-present: Group Leader, Beatson Institute for Cancer Research
1982-1989: Associate Professor Microbiology & Immunology, University of Texas, Southwestern Medical School, Dallas, USA
1977-1982: Assistant Professor Microbiology & Immunology, University of Texas, Southwestern Medical School, Dallas, USA
1975-1977: Postdoctoral Fellow with Robin Weiss, Imperial Cancer Research Fund, London

Committee membership
2007-2009: Cancer Research UK Studentship Committee
1993-present: Chair, Beatson International Cancer Conference Organising Committee

Fleming YM, Ferguson GJ, Spender LC, Larsson J, Karlsson S, Ozanne BW, Grosse R, Inman GJ. TGFβ-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation. Oncogene, Published online 15 December 2008; DOI: 10.1038/onc.2008.449

Borland G, Edkins AL, Acharya M, Matheson J,White LJ, Allen JM, Bonnefoy JY, Ozanne BW, Cushley W (2007). αvβ5 integrin sustains growth of human pre-B cells through an RGD-independent interaction with a basic domain of the CD23 protein. J Biol Chem. 282, 27315-26.

Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC (2007). Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments. Dev Cell 13: 496-510.

Macpherson IR, Hooper S, Serrels A, McGarry L, Ozanne BW, Harrington K, Frame MC, Sahai E, Brunton VG (2007). p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism. Oncogene 26, 5214-28.

Ozanne BW, Spence HJ, McGarry LC, Hennigan RF (2007). Transcription factors control invasion: AP-1 the first among equals. Oncogene 26, 1-10.

Carragher NO, Walker SM, Scott-Carragher LA, Harris F, Sawyer TK, Brunton VG, Ozanne BW, Frame MC (2006). Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function. Oncogene 25, 5726-40.

Ozanne BW, Spence HJ, McGarry LC, Hennigan RF (2006). Invasion is a genetic program regulated by transcription factors. Current Opinion Genetics & Development 16, 65-70.

Spence HJ, McGarry L, Chew CS, Carragher NO, Scott-Carragher LA, Yuan Z, Croft DR, Olson MF, Frame M, Ozanne BW (2006). AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins. Mol & Cell Biol. 26, 1480-95.

Tovey SM, Reeves JR, Stanton P, Ozanne BW, Bartlett JM, Cooke TG. (2006). Low expression of HER2 protein in breast cancer is biologically significant. J Pathol. 210, 358-62.

Tsirimonaki E, Ullah R, Marchetti B, Ashrafi GH, McGarry L, Ozanne B, Campo MS (2006). Similarities and differences between the E5 oncoproteins of bovine papillomaviruses type 1 and type 4: cytoskeleton, motility and invasiveness in E5-transformed bovine and mouse cells. Virus Res. 115, 158-68.