Scientific Report 2010 Norman (210.24 kB)

Key Publications

Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC (2007). Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments. Dev Cell 13, 496-510.
Selected as a PaperPick by Developmental Cell Editorial Board member Joan Brugge: see www.cell.com/developmental-cell/paperpicks for comments and a video by the authors.

White DP, Caswell PT, Norman JC (2007). αvβ3 and α5β1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. J Cell Biol 177, 515-25.

Roberts MS, Barry ST, Woods AJ, van der Sluijs P, Norman JC (2001). PDGF regulated rab-4 dependent recycling of αvβ3 integrin from early endosomes is necessary for cell adhesion and spreading. Curr Biol. 11, 1-20.

Education and qualifications
1992: PhD, University of London, Supervisor Alison Gurney
1985: BSc, Biochemistry (Second Class Honours), University of Southampton

Appointments
2005-present: Group Leader, Beatson Institute for Cancer Research
2000-2005: Lecturer, Dept. Biochemistry, University of Leicester
1998-2003: Wellcome Career Development Fellow, Dept. Biochemistry, University of Leicester
1996-1998: Postdoctoral Fellow, Dept. Biochemistry, University of Leicester
1994-1996: Postdoctoral Fellow, Physiological Laboratory, University of Cambridge
1992-1994: Postdoctoral Fellow, Dept. Physiology, University College London

Honours and awards
Wellcome Trust Career Development Award, 1998-2003

2011
Muller PA, Vousden KH, Norman JC (2011). p53 and its mutants in tumor cell migration and invasion. J Cell Biol. 192, 209-18.

Rainero E, Norman JC (2011). New roles for lysosomal trafficking in morphogen gradient sensing. Sci Signal 4, pe24.

Murdoch H, Vadrevu S, Prinz A, Dunlop AJ, Klussmann E, Bolger GB, Norman JC, Houslay MD (2011). Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function. J Cell Sci. 124, 2253-66.

2010
di Blasio L, Droetto S, Norman J, Bussolino F, Primo L (2010). Protein kinase D1 regulates VEGF-A-induced alphavbeta3 integrin trafficking and endothelial cell migration. Traffic 11, 1107-18.

Eva R, Dassie E, Caswell PT, Dick G, ffrench- Constant C, Norman JC, Fawcett JW (2010). Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells. J Neurosci. 30, 11654-69.

Kelly EE, Horgan CP, Adams C, Patzer TM, Ni Shuilleabhain DM, Norman JC, McCaffrey MW (2010). Class I Rab11-Family Interacting Proteins are binding targets for the Rab14 GTPase. Biol Cell. 102, 51-62.

2009
Jones MC, Caswell PT, Moran-Jones K, Roberts M, Barry ST, Gampel A, Mellor H, Norman JC (2009). VEGFR1 (Flt1) Regulates Rab4 Recycling to Control Fibronectin Polymerization and Endothelial Vessel Branching. Traffic 10, 754-66.

Moran-Jones K, Grindlay J, Jones M, Smith R, Norman JC (2009). hnRNP A2 Regulates Alternative mRNA Splicing of TP53INP2 to Control Invasive Cell Migration. Cancer Res. 69, 9219-27.

Muller PAJ, Caswell PT, Doyle B, Iwanicki MP,Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH (2009). Mutant p53 drives invasion by promoting integrin recycling. Cell 139, 1327-41.

Reynolds AR, Hart IR, Watson AR, Welti JC, Silva RG, Robinson SD, Da Violante G, Gourlaouen M, Salih M, Jones MC, Jones DT, Saunders G, Kostourou V, Perron-Sierra F, Norman JC, Tucker GC, Hodivala-Dilke KM (2009). Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med. 15, 392-400.

Valdembri D, Caswell PT, Anderson KI, Schwarz JP, Konig I, Astanina E, Caccavari F, Norman JC, Humphries MJ, Bussolino F, Serini G (2009). Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS Biol. 7, e25.

Caswell PT, Vadrevu S, Norman JC (2009). Integrins: masters and slaves of endocytic transport. Nat Rev Mol Cell Biol. 10, 843-53.

Mills GB, Jurisica I, Yarden Y, Norman JC (2009). Genomic amplicons target vesicle recycling in breast cancer. J Clin Invest. 119, 2123-7.

2008
Kim M, Jang H-R, Kim J-H, Noh S-M, Song K-S, Cho J-S, Jeong H-Y, Norman JC, Caswell PT, Kang GH, Kim S-Y, Yoo H-S, Kim YS (2008). Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. Carcinogenesis 29, 629-37.

Caswell PT, Chan M, Lindsay AJ, McCaffrey MW, Boettiger D, Norman JC (2008). Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments. J Cell Biol. 183, 143-55.

2007
Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC (2007). Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments. Dev Cell 13, 496-510.

Muddasani P, Norman JC, Ellman M, Van Wijnen AJ, Im HJ (2007). Basic fibroblast growth factor activates the MAPK and NFκB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. J Biol Chem 282, 31409-21.

White DP, Caswell PT, Norman JC (2007). αvβ3 and α5β1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. J Cell Biol 177, 515-25.

 

Post-docs: Andrew Campbell, Jesica Diaz, Elena Rainero (West of Scotland Women's Bowling Association),
Peter van den Berghe

Scientific Officer: Joan Grindlay

Associate Clinical Scientist: Iain MacPherson

PhD Students: Christine Adams, Anne von Thun