Link to Norman Scientific Report 2008 158.75 Kb

Key Publications

Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC (2007). Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments. Dev Cell 13, 496-510.

White DP, Caswell PT, Norman JC (2007). αvβ3 and α5β1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. J Cell Biol 177, 515-25.

Roberts MS, Barry ST, Woods AJ, van der Sluijs P, Norman JC (2001). PDGF regulated rab-4 dependent recycling of αvβ3 integrin from early endosomes is necessary for cell adhesion and spreading. Curr Biol. 11, 1-20.

Education and qualifications
1992: PhD, University of London, Supervisor Alison Gurney
1985: BSc, Biochemistry (Second Class Honours), University of Southampton

Appointments
2005-present: Group Leader, Beatson Institute for Cancer Research
2000-2005: Lecturer, Dept. Biochemistry, University of Leicester
1998-2003: Wellcome Career Development Fellow, Dept. Biochemistry, University of Leicester
1996-1998: Postdoctoral Fellow, Dept. Biochemistry, University of Leicester
1994-1996: Postdoctoral Fellow, Physiological Laboratory, University of Cambridge
1992-1994: Postdoctoral Fellow, Dept. Physiology, University College London

Honours and awards
Wellcome Trust Career Development Award, 1998-2003

Jones MC, Caswell PT, Moran-Jones K, Roberts MS, Barry ST, Gampel A, Mellor H, Norman JC (2009). VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymeristion and endothelial vessel branching. Traffic, in press.

Reynolds AR, Hart IR, Watson A, Welti JC, Silva R, Robinson SD, Da Violante G, Gourlaouen M, Salih M, Jones MC, Jones DT, Saunders G, Kostourou V, Perron-Sierra F, Norman JC, Tucker GC, Hodivala-Dilke KM (2009). Stimulation of tumor growth and angiogenesis by low concentrations of RGDmimetic integrin inhibitors. Nature Med., in press.

Kim M, Jang H-R, Kim J-H, Noh S-M, Song K-S, Cho J-S, Jeong H-Y, Norman JC, Caswell PT, Kang GH, Kim S-Y, Yoo H-S, Kim YS (2008). Epigenetic inactivation of protein kinase D1 in gastric cancer and its role in gastric cancer cell migration and invasion. Carcinogenesis 29, 629-37.

Valdembri D, Caswell PT, Anderson KI, Schwarz J, Konig I, Astanina E, Caccavari F, Norman JC, Humphries MJ, Bussolino F, Serini G (2009). Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PloS Biology 7, e25.

Caswell PT, Chan M, Lindsay AJ, McCaffrey MW, Boettiger D, Norman JC (2008). Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments. J Cell Biol. 183, 143-55.

Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC (2007). Rab25 associates with α5β1 integrin to promote invasive migration in 3D microenvironments. Dev Cell 13, 496-510.

Muddasani P, Norman JC, Ellman M, Van Wijnen AJ, Im HJ (2007). Basic fibroblast growth factor activates the MAPK and NFκB pathways that converge on Elk-1 to control production of matrix metalloproteinase-13 by human adult articular chondrocytes. J Biol Chem 282, 31409-21.

White DP, Caswell PT, Norman JC (2007). αvβ3 and α5β1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration. J Cell Biol 177, 515-25.

Caswell PT, Norman JC (2006). Integrin trafficking and the control of cell migration. Traffic 7, 14-21.

Gampel A, Moss L, Jones MC, Brunton V, Norman JC, Mellor H (2006). VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment. Blood 108, 2624-31.

Jones MC, Caswell PT, Norman JC (2006). Endocytic recycling pathways: emerging regulators of cell migration. Curr Opin Cell Biol. 18, 549-57.

Thomas RA, Norman JC, Huynh TT, Williams B, Bolton SJ, Wardlaw AJ (2006). Mechanical stretch has contrasting effects on mediator release from bronchial epithelial cells, with a rho-kinase-dependent component to the mechanotransduction pathway. Respiratory Medicine 100, 1588-97.