Scientific Report 2010 Anderson (305.03 kB)

Key Publications

Weisswange I, Bretschneider T, Anderson KI (2005). The leading edge is a lipid diffusion barrier. J Cell Sci. 118, 4375-80.

Gerisch G, Bretschneider T, Muller-Taubenberger A, Simmeth E, Ecke M, Diez S, Anderson K (2004). Mobile actin clusters and travelling waves in cells recovering from actin depolymerization. Biophys J. 87, 3493-503.

Anderson KI, Wang YL, Small JV (1996). Coordination of protrusion and translocation of the keratocyte involves rolling of the cell body. J Cell Biol. 134, 1209-18.

Education and qualifications
1997: PhD, University of Salzburg, Supervisor Vic Small
1992: BSc, Microbiology (with distinction), University of Maine
1992: BA, German (with distinction), University of Maine

Appointments
2005-present: Group Leader, Beatson Institute for Cancer Research
2000-2005: Group Leader, Max Planck Institute for Molecular Cell Biology and Genetics, Germany
1997-2000: Postdoctoral Fellow with Rob Cross, MCRI, Oxted

Committee membership
2007-present: ELMI Steering Committee
2007-present: Advisory Board, Rockefeller University Bio-Imaging Center

2011
Timpson P, McGhee EJ, Morton JP, von Kriegsheim A, Schwarz JP, Karim SA, Doyle B, Quinn JA, Carragher NO, Edward M, Olson MF, Frame MC, Brunton VG, Sansom OJ, Anderson KI (2011). Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res. 71, 747-57.

Schwarz JP, Konig I, Anderson KI (2011). Characterizing System Performance in Total Internal Reflection Fluorescence Microscopy. Methods Mol Biol. 769, 373-86.

Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schroder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF (2011). Actomyosin-mediated cellular tension drives increased tissue stiffness and beta-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell 19, 776-91.

2010
Canel M, Serrels A, Anderson KI, Frame MC, Brunton VG (2010). Use of photoactivation and photobleaching to monitor the dynamic regulation of E-cadherin at the plasma membrane. Cell Adh Migr. 4, 491-501.

Li A, Dawson JC, Forero-Vargas M, Spence HJ, Yu X, Konig I, Anderson K, Machesky LM (2010). The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. Curr Biol. 20, 339-45.

Rooney C, White G, Nazgiewicz A, Woodcock SA, Anderson KI, Ballestrem C, Malliri A (2010). The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly. EMBO Rep. 11, 292-8.

Scott RW, Hooper S, Crighton D, Li A, Konig I, Munro J, Trivier E, Wickman G, Morin P, Croft DR, Dawson J, Machesky L, Anderson KI, Sahai EA, Olson MF (2010). LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J Cell Biol. 191, 169-85.

Serrels B, Sandilands E, Serrels A, Baillie G, Houslay MD, Brunton VG, Canel M, Machesky LM, Anderson KI, Frame MC (2010). A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity. Curr Biol. 20, 1086-92.

2009
Serrels A, Timpson P, Canel M, Schwarz JP, Carragher NO, Frame MC, Brunton VG, Anderson KI (2009). Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development. Cancer Res. 69, 2714-9.

Bretschneider T, Anderson K, Ecke M, Muller-Taubenberger A, Schroth-Diez B, Ishikawa-Ankerhold HC, Gerisch G (2009). The Three-Dimensional Dynamics of Actin Waves, a Model of Cytoskeletal Self-Organization. Biophysical J. 96, 2888–2900.

Densham R, O'Neill E, Munro J, König I, Anderson K, Kolch W, Olson MF (2009). MST kinases monitor actin cytoskeletal integrity and signal via JNK stress-activated kinase to regulate p21Waf1/Cip1 stability. Mol Cell Biol. 29, 6380-90.

McCarron JG, Olson ML, Currie S, Wright AJ, Anderson KI, Girkin JM (2009). Elevations of intracellular calcium reflect normal voltage-dependent behavior, and not constitutive activity, of voltage-dependent calcium channels in gastrointestinal and vascular smooth muscle. J Gen Physiol. 133, 439-57.

Valdembri D, Caswell PT, Anderson KI, Schwarz JP, König I, Astanina E, Caccavari F, Norman JC, Humphries MJ, Bussolino F, Serini G (2009). Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. PLoS Biol. 7, e25.

Timpson P, Serrels A, Canel M, Frame MC, Brunton VG, Anderson KI (2009). Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo. Cell Adh Migr. 3, 351-4.

2008
Konig I, Schwarz JP, Anderson KI (2008). Fluorescence lifetime imaging: Association of cortical action with a PIP3-rich membrane compartment. Eur J Cell Biol. 87, 735-41.

Patel H, Konig I, Tsujioka M, Frame MC, Anderson KI, Brunton VG (2008). The multi-FERM-domain-containing protein FrmA is required for turnover of paxillin-adhesion sites during cell migration of Dictyostelium. J Cell Sci. 121, 1159-64.

2007
Anderson KI, Sanderson J, Peychl J (2007). Design and function of a light microscopy facility. In S. Shorte, ed. Imaging Cellular and Molecular Biological Functions. Heidelberg: Springer; 93-114.

Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC (2007). Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Developmental Cell 13, 496-510.

Muller-Taubenberger A, Anderson KI (2007). Recent advances using green and red fluorescent protein variants. Applied Microbiol Biotechnol. 77, 1-12.

 

Post-docs: Shereen Kadir, Paul Timpson

Scientific Officer: Juliane Schwarz

PhD Students: Zahra Erami, Max Nobis