Biography
Education and qualifications
1993: PhD, The Johns Hopkins School of Medicine, Supervisor Thomas D. Pollard
1987: BSc, Chemistry and Biology (GPA 3.98/4.00), Alma College, USA
Appointments
2007-present: MRC Senior Research Fellow & Professor of Cell Biology, Beatson Institute for Cancer Research
1999-2007: MRC Career Development Fellow, MRC Senior Research Fellow & Professor of Cell Biology, School of Biosciences University of Birmingham
1997-1998: MRC Career Development Fellow with Alan Hall, MRC-LMCB, London
1995-1997: Damon Runyon Walter Winchell Cancer Research Posdoctoral Fellow with Alan Hall, MRC-LMCB, London
1993-1995: Damon Runyon Walter Winchell Cancer Research Postdoctoral Fellow with Rob Kay, MRC-LMB, Cambridge
Committee membership
2009-present: The Wellcome Trust Fellowships Interview Committee
2007-present: AICR Grants Board
Recent Publications
Calaminus SD, Thomas S, McCarty OJ, Machesky LM, Watson SP (2008). Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading. J Thromb Haemost. 6, 1944-52.
Heung MY, Visegrady B, Fütterer K, Machesky LM (2008). Identification of the insulin-responsive tyrosine phosphorylation sites on IRSp53. Eur J Cell Biol. 87, 699-708.
Johnston SA, Bramble JP, Yeung CL, Mendes PM, Machesky LM (2008). Arp2/3 Complex Activity on Filopodia of Spreading Cells. BMC Cell Biol. 9, 65.
Machesky L, Jurdic P, Hinz B (2008). Grab, stick, pull and digest: the functional diversity of actin-associated matrix-adhesion structures. Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion. EMBO Rep. 9, 139-43.
Machesky LM (2008). Lamellipodia and filopodia in metastasis and invasion. FEBS Lett. 582, 2102-11.
Zech T, Machesky L (2008). Rab5 and rac team up in cell motility. Cell 134, 18-20.
Bathe FS, Rommelaere H, Machesky LM (2007). Phenotypes of myopathy-related actin mutants in differentiated C2C12 myotubes. BMC Cell Biol. 8, 2.
Calaminus SD, Auger JM, McCarty OJ, Wakelam MJ, Machesky LM and Watson, SP (2007). Myosin-IIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability. J Thromb Haemost. Jul 23.
Calaminus SD, McCarty OJ, Auger JM, Pearce AC, Insall RH, Watson SP, Machesky LM (2007). A major role for Scar/WAVE-1 downstream of GPVI in platelets. J Thromb Haemost. 5, 535-41.
Futterer K and Machesky LM (2007). “Wunder” F-BAR domains: going from pits to vesicles. Cell 129, 655-7.
Legg JA, Bompard G, Dawson J, Morris HL, Andrew N, Cooper L, Johnston SA, Tramountanis G, Machesky LM (2007). N-Wasp involvement in dorsal ruffle formation in mouse embryonic fibroblasts. Mol Biol Cell. 18, 678-87.
Millard TH, Dawson J, Machesky LM (2007). Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties. J Cell Sci. 120, 1663-72.
Thomas SG, Calaminus SD, Auger JM, Watson SP, Machesky LM (2007). Studies on the actin-binding protein HS1 in platelets. BMC Cell Biol. 8, 46.
Uhrig JF, Mutondo M, Zimmermann I, Deeks MJ, Machesky LM, Thomas P, Uhrig S, Rambke C, Hussey PJ, Hulskamp M (2007). The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis. Development 134, 967-77.
Futterer K, Machesky LM (2007). “Wunder” F-BAR domains: going from pits to vesicles. Cell 129, 655-7.
Machesky LM, Johnston SA (2007). MIM: a multifunctional scaffold protein. J Mol Med. 85, 569-76.
Ardern H, Sandilands E, Machesky LM, Timpson P, Frame MC, Brunton VG (2006). Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex. Cell Motil Cytoskeleton 63, 6-13.
Klooster JP, Evers EE, Janssen L, Machesky LM, Michiels F, Hordijk P, Collard JG (2006). Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerisation. Biochem J. 397, 39-45.
Baldassarre M, Ayala I, Beznoussenko G, Giacchetti G, Machesky LM, Luini A, Buccione R (2006). Actin dynamics at sites of extracellular matrix degradation. Eur J Cell Biol. 85, 1217-31.
McCarty OJ, Calaminus SD, Berndt MC, Machesky LM, Watson SP (2006). von Willebrand factor mediates platelet spreading through glycoprotein Ib and alpha(IIb)beta3 in the presence of botrocetin and ristocetin, respectively. J Thromb Haemost. 4, 1367-78.
Dawson JC, Legg JA, Machesky LM (2006). Bar domain proteins: a role in tubulation, scission and actin assembly in clathrin-mediated endocytosis.Trends Cell Biol. Aug 30.
Mobilisation of the actin cytoskeleton is important for cell migration, shape change, and interactions with other cells and the environment. Additionally, alterations in cytoskeletal signalling pathways are increasingly being recognised as important for cancer invasion and metastasis. 
Link to Machesky Scientific Report 2008
