Recent Publications
2012
Dawson JC, Bruche S, Spence HJ, Braga VMM, Machesky LM. Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1. PLoS One; in press 2012
Yu X, Machesky LM. Cells assemble invadopodia-like structures and invade into Matrigel in a matrix metalloprotease dependent manner in the circular invasion assay. PLoS One; in press 2012
2011
Dawson JC, Timpson P, Kalna G, Machesky LM. Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells. Oncogene doi: 10.1038/onc.2011.376, published online 19 Sep 2011
Li A, Ma Y, Yu X, Mort RL, Lindsay CR, Stevenson D, Strathdee D, Insall RH, Chernoff J, Snapper SB, Jackson IJ, Larue L, Sansom OJ, Machesky LM. Rac1 Drives Melanoblast Organization during Mouse Development by Orchestrating Pseudopod- Driven Motility and Cell-Cycle Progression. Dev Cell 2011; 21: 722-
34
Zech T, Calaminus SDJ, Caswell PT, Spence HJ, Carnell MJ, Insall RH,
Norman JC, Machesky LM. The Arp2/3 activator WASH regulates alpha-5
beta-1 integrin mediated invasive migration. J Cell Sci doi: 10.1242/
jcs.080986, published online 23 Nov 2011
Carnell M, Zech T, Calaminus SD, Ura S, Hagedorn M, Johnston SA, May RC, Soldati T, Machesky LM, Insall RH (2011). Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis. J Cell Biol. 193, 831-9.
Heath RJ, Leong JM, Visegrady B, Machesky LM, Xavier RJ (2011). Bacterial and Host Determinants of MAL Activation upon EPEC Infection: The Roles of Tir, ABRA, and FLRT3. PLoS Pathog. 7, e1001332.
Lindsay CR, Lawn S, Campbell AD, Faller WJ, Rambow F, Mort RL, Timpson P, Li A, Cammareri P, Ridgway RA, Morton JP, Doyle B, Hegarty S, Rafferty M, Murphy IG, McDermott EW, Sheahan K, Pedone K, Finn AJ, Groben PA, Thomas NE, Hao H, Carson C, Norman JC, Machesky LM, Gallagher WM, Jackson IJ, Van Kempen L, Beermann F, Der C, Larue L, Welch HC, Ozanne BW, Sansom OJ. P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun doi: 10.1038/ncomms1560, published online 22 Nov 2011
Ramsay AK, McCracken SRC, Soofi M, Morland R, Fleming J, Yu AX, Machesky L, Nixon C, Edwards DE, Nuttall RK, Seywright M, Keller E, Leung HY (2011). ERK5 signalling in prostate cancer promotes an invasive phenotype. Br J Cancer 104, 664-72.
Thomas SG, Calaminus SD, Machesky LM, Alberts AS, Watson SP (2011). G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho Kinase in platelets. J Thromb Haemost. 2011 May 23. doi: 10.1111/j.1538-7836.2011.04357.x. [Epub ahead of print].
Veltman DM, Auciello G, Spence HJ, Machesky LM, Rappoport JZ, Insall RH (2011). Functional analysis of
Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis. Biochem J. 436, 45-52.
2010
Li A, Dawson JC, Forero-Vargas M, Spence HJ, Yu
X, Konig I, Anderson K, Machesky LM (2010).
The actin-bundling protein fascin stabilizes actin in
invadopodia and potentiates protrusive invasion.
Curr Biol. 20, 339-45.
Visegrady B, Machesky LM (2010). Myopathy-causing actin mutations
promote defects in serum-response factor signalling. Biochem J. 427,
41-8.
Scott RW, Hooper S, Crighton D, Li A, Konig I,
Munro J, Trivier E, Wickman G, Morin P, Croft DR,
Dawson J, Machesky L, Anderson KI, Sahai EA,
Olson MF (2010).
LIM kinases are required for invasive path
generation by tumor and tumor-associated stromal
cells. J Cell Biol. 191, 169-85.
Brooks SP, Coccia M, Tang HR, Kanuga N,
Machesky LM, Bailly M, Cheetham ME,
Hardcastle AJ (2010).
The Nance-Horan syndrome protein encodes a
functional WAVE homology domain (WHD) and is
important for co-ordinating actin remodelling and
maintaining cell morphology. Hum Mol Genet. 19, 2421-32.
Serrels B, Sandilands E, Serrels A, Baillie G, Houslay
MD, Brunton VG, Canel M, Machesky LM, Anderson
KI, Frame MC (2010).
A complex between FAK, RACK1, and PDE4D5
controls spreading initiation and cancer cell polarity.
Curr Biol. 20, 1086-92.
Stein T, Cosimo E, Yu X, Smith PR, Simon R,
Cottrell L, Pringle MA, Bell AK, Lattanzio L, Sauter
G, Lo Nigro C, Crook T, Machesky LM, Gusterson
BA (2010).
Loss of reelin expression in breast cancer is
epigenetically controlled and associated with poor prognosis. Am J Pathol. 177, 2323-33.
2009
Mardakheh FK,Yekezare M, Machesky LM, Heath JK (2009). Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling. J Cell Biol. 187, 265-77.
Vandamme D, Lambert E,Waterschoot D,Tondeleir D,Vandekerckhove J, Machesky LM, Constantin B, Rommelaere H,Ampe C (2009). Phenotypes induced by NM causing alpha-skeletal muscle actin mutants in fibroblasts, Sol 8 myoblasts and myotubes. BMC Res Notes 2, 40.
Insall RH, Machesky LM (2009). Actin dynamics at the leading edge: from simple machinery to complex networks. Dev Cell 17, 310-22.
Machesky LM, Tang HR (2009). Actin-based protrusions: promoters or inhibitors of cancer invasion? Cancer Cell 16, 5-7.
2008
Calaminus SD, Thomas S, McCarty OJ, Machesky LM, Watson SP (2008). Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreading. J Thromb Haemost. 6, 1944-52.
Heung MY, Visegrady B, Fütterer K, Machesky LM (2008). Identification of the insulin-responsive tyrosine phosphorylation sites on IRSp53. Eur J Cell Biol. 87, 699-708.
Johnston SA, Bramble JP, Yeung CL, Mendes PM, Machesky LM (2008). Arp2/3 Complex Activity on Filopodia of Spreading Cells. BMC Cell Biol. 9, 65.
Machesky L, Jurdic P, Hinz B (2008). Grab, stick, pull and digest: the functional diversity of actin-associated matrix-adhesion structures. Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion. EMBO Rep. 9, 139-43.
Machesky LM (2008). Lamellipodia and filopodia in metastasis and invasion. FEBS Lett. 582, 2102-11.
Zech T, Machesky L (2008). Rab5 and rac team up in cell motility. Cell 134, 18-20.
2007
Bathe FS, Rommelaere H, Machesky LM (2007). Phenotypes of myopathy-related actin mutants in differentiated C2C12 myotubes. BMC Cell Biol. 8, 2.
Calaminus SD, Auger JM, McCarty OJ, Wakelam MJ, Machesky LM and Watson, SP (2007). Myosin-IIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability. J Thromb Haemost. Jul 23.
Calaminus SD, McCarty OJ, Auger JM, Pearce AC, Insall RH, Watson SP, Machesky LM (2007). A major role for Scar/WAVE-1 downstream of GPVI in platelets. J Thromb Haemost. 5, 535-41.
Futterer K and Machesky LM (2007). “Wunder” F-BAR domains: going from pits to vesicles. Cell 129, 655-7.
Legg JA, Bompard G, Dawson J, Morris HL, Andrew N, Cooper L, Johnston SA, Tramountanis G, Machesky LM (2007). N-Wasp involvement in dorsal ruffle formation in mouse embryonic fibroblasts. Mol Biol Cell. 18, 678-87.
Millard TH, Dawson J, Machesky LM (2007). Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties. J Cell Sci. 120, 1663-72.
Thomas SG, Calaminus SD, Auger JM, Watson SP, Machesky LM (2007). Studies on the actin-binding protein HS1 in platelets. BMC Cell Biol. 8, 46.
Uhrig JF, Mutondo M, Zimmermann I, Deeks MJ, Machesky LM, Thomas P, Uhrig S, Rambke C, Hussey PJ, Hulskamp M (2007). The role of Arabidopsis SCAR genes in ARP2-ARP3-dependent cell morphogenesis. Development 134, 967-77.
Futterer K, Machesky LM (2007). “Wunder” F-BAR domains: going from pits to vesicles. Cell 129, 655-7.
Machesky LM, Johnston SA (2007). MIM: a multifunctional scaffold protein. J Mol Med. 85, 569-76.
Mobilisation of the actin cytoskeleton is important for cell migration, shape change, and interactions with other cells and the environment. Additionally, alterations in cytoskeletal signalling pathways are increasingly being recognised as important for cancer invasion and metastasis. 
Scientific Report 2010 Machesky (
