Lab Report
Link to Leung Scientific Report 2008 177.51 Kb
Key Publications
Heer R, Collins AT, Robson CN, Shenton BK, Leung HY (2006). Keratinocyte growth factor (KGF) suppresses α2β1 integrin function and promotes differentiation of the transient amplifying population in human prostatic epithelium. J Cell Sci. 119, 1416-24.
Mehta PB, Jenkins BL, McCarthy L, Thilak L, Robson CN, Neal DE, Leung HY (2003). MEK5 over-expression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. Oncogene 22, 1381-9.
Dorkin T, Robinson M, Neal DE, Leung HY (1999). FGF8 over-expression in prostate cancer is associated with decreased patient survival. Oncogene 18, 2755-61.
Biography
Education and qualifications
1986: MB ChB, University of Aberdeen
1990: FRCS (Glas) , Royal College of Physicians and Surgeons of Glasgow
1994: PhD, University of London, Supervisor Nick Lemoine
1997: FRCS (Urol), Royal Colleges of Surgeons (UK & Ireland)
Appointments
2006-present: Professor of Urology and Surgical Oncology, University of Glasgow; Group leader, Beatson Institute for Cancer Research; Consultant Urological Surgeon, NHS Greater Glasgow and Clyde
2002-2006: Professor of Urological Oncology, University of Newcastle upon Tyne
1999-2002: Senior Lecturer, University of Newcastle upon Tyne
1995-1998: Clinical Lecturer, University of Newcastle upon Tyne
1990-1994: Clinical Research Fellow, Imperial Cancer Research Fund
1987-1989: Surgical Registrar, Birmingham Rotation
Honours and awards
The Karl Storz Harold Hopkins Golden Telescope Award, British Association of Urological Surgeons, 2008
Founding member of the Northern Institute for Cancer Research, University of Newcastle upon Tyne
Recent Publications
McCracken SR, Ramsay A, Heer R, Mathers ME, Jenkins BL, Edwards J, Robson CN, Marquez R, Cohen P, Leung HY (2008). Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer. Oncogene 27, 2978-88.
Dovedi SJ, Kirby JA, Davies BR, Leung H, Kelly JD (2008). Celecoxib has potent antitumour effects as a single agent and in combination with BCG immunotherapy in a model of urothelial cell carcinoma. Eur Urol. 54, 621-30.
Rajan P, Gaughan L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY, Elliott DJ (2008). The RNA-binding and adaptor protein Sam68 modulates signal-dependent splicing and transcriptional activity of the androgen receptor. J Path 215, 67-77.
Whitaker HC, Girling J, Warren AY, Leung HY, Mills IG, Neal DE (2008). Alterations in beta-catenin expression and localization in prostate cancer. Prostate 68, 1196-205.
Clark EL, Coulson A, Dalgliesh C, Rajan P, Nicol SM, Fleming S, Heer R, Gaughan L, Leung HY, Elliott DJ, Fuller-Pace FV, Robson CN (2008). The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer. Cancer Res. 68, 7938-46.
Rogerson L, Darby S, Jabbar T, Mathers ME, Leung HY, Robson CN, Sahadevan K, O'Toole K, Gnanapragasam VJ (2008). Application of transcript profiling in formalin-fixed paraffin-embedded diagnostic prostate cancer needle biopsies. BJU Int. 102, 364-70.
Ahmad I, Sansom OJ, Leung HY (2008). Advances in mouse models of prostate cancer. Expert Rev Mol Med. 10, e16.
Rowland JG, Robson JL, Simon WJ, Leung HY, Slabas AR (2007). Evaluation of an in vitro model of androgen ablation and identification of the androgen responsive proteome in LNCaP cells. Proteomics 7, 47-63.
Armstrong K, Robson CN, Leung HY (2006). Transcriptional activation of FGF8 by TSA is mediated by NFkB pathway. Prostate 66, 1223-34.
Heer R, Collins AT, Robson CN, Shenton BK, Leung HY (2006). Keratinocyte growth factor (KGF) suppresses α2β1 integrin function and promotes differentiation of the transient amplifying population in human prostatic epithelium. J Cell Sci. 119, 1416-24.
Lo TL, Fong CW, Yusoff C, McKie AB, Chua MS, Leung HY, Guy GR (2006). Sprouty and cancer: the first terms report. Cancer Letters 242, 141-50.
Fong CW, Lo TL, Yusoff C, McKie AB, Chua MS, Leung HY, Guy GR (2006). Sprouty 2, an inhibitor of MAPK signaling, is down-regulated in hepatocellular carcinoma. Cancer Res. 66, 2048-58.
Darby S, Khan MM, Stockley J, Robson CN, Leung HY, Gnanapragasam VJ (2006). Loss of Sef (Similar expression to FGF) expression is associated with high grade and metastatic prostate cancer. Oncogene 25, 4122-7.
Logan IR, Gaughan L, McCracken SR, Sapountzi V, Leung HY, Robson CN (2006). Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer. Mol Cell Biol. 26, 6502-10.
Prostate cancer is a major global health issue, and its management remains controversial. A refined understanding of how aberrant signalling drives prostate carcinogenesis will help develop better prognostic biomarkers and therapeutic targets. FGF receptor and ERK5 in particular have been implicated in prostate cancer. 
