Link to Sansom Scientific Report 2008 326.48 Kb

Key Publications

Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos DA, Clevers H, Clarke AR (2007). c-Myc deletion rescues Apc deficiency in the small intestine. Nature 446, 676-9.

Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, Newton IP, Batlle E, Simon-Assmann P, Clevers H, Nathke IS, Clarke AR, Winton DJ (2004). Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev. 18, 1385-90.

Sansom OJ, Berger J, Bishop SM, Hendrich B, Bird A, Clarke AR (2003). Deficiency of Mbd2 suppresses intestinal tumorigenesis. Nat Genet. 34, 145-7.

Education and qualifications
2001: PhD, University of Edinburgh, Supervisors Alan Clarke and Andrew Wylie
1997: MRes, Biology, University of Manchester
1996: BSc, Genetics (First Class Honours), University of Nottingham

Appointments
2005-present: Group Leader, Beatson Institute for Cancer Research
2000-2005: Postdoctoral Fellow with Alan Clarke, University of Cardiff

Honours and awards
BACR/AstraZeneca Young Scientist Frank Rose Award, 2007

Barker N, Ridgway RA, Van Es J, Clarke AR, Sansom OJ, Clevers H (2009). Intestinal stem cells as the origin of intestinal cancer. Nature 457, 608-11.

Shorning BY, Zabkiewicz J, McCarthy A, Pearson HB, Winton DJ, Sansom OJ, Ashworth A, Clarke AR (2009). Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. : PLoS ONE 4, 4264.

Ridgway RA, Athineos DA, Sansom OJ (2009). c-Myc is not essential for the skin and liver phenotypes following beta-catenin activation. Cell Cycle, in press.

Serrels A, Serrels B, Ashton GH, Doyle BD, Frame MC, Sansom OJ, Brunton V (2009). Src inhibition slows carcinogenesis in the skin. Carcinogenesis 30, 249-57.

Marsh V, Winton DJ, Williams GT, Dubois N, Trumpp A, Sansom OJ, Clarke AR (2008). PTEN is not required for intestinal stem cells but loss accelerates tumor progression. Nat Genet. 40, 1436-44.

Reed KR, Athineos DA, Meniel VS, Wilkins JA, Ridgway RA, Muncan V, Clarke AR, Sansom OJ (2008). Beta-catenin and not c-Myc rescues the phenotypes of Apc loss in the liver. PNAS 105, 18919-23.

Stevens C, Lin Y, Harrison B, Burch L, Ridgway RA, Sansom O, Hupp T (2009), Peptide combinatorial libraries identify TSC2 as a DAPK death domain binding protein and reveal a stimulatory role for DAPK in mTORC1 signalling. J Biol Chem. 284, 334-44.

Phesse TJ, Parry L, Reed KR, Ewan KB, Dale TC, Sansom OJ, Clarke AR (2008). Deficiency of Mbd2 attenuates Wnt signalling. Mol Cell Biol. 19, 6094-103.

Patek CE, Arends MJ, Rose L, Luo F, Walker M, Devenney PS, Berry RL, Lawrence NJ, Ridgway RA, Sansom OJ, Hooper ML (2008). The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine. BMC Gastroenterol. 8, 24.

Reed KR, Meniel VS, Marsh V, Cole A, Sansom OJ, Clarke AR (2008). A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer 5, 162.

Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR (2007). c-Myc deletion rescues Apc deficiency in the small intestine. Nature 446, 676-9.

Patek CE, Arends MJ, Wallace WA, Luo F, Hagan S, Brownstein DG, Rose L, Devenney PS, Walker M, Plowman SJ, Berry RL, Kolch W, Sansom OJ, Harrison DJ, Hooper ML (2008). Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis. Exp Cell Res. 314, 1105-14.

Berger J, Sansom OJ, Clarke AR, Bird A (2007). MBD2 is required for correct spatial gene expression in the gut. Mol Cell Biol. 27, 4049-57.

Sansom OJ, Mansergh F, Evans M, Wilkins JA, Clarke AR (2007). Deficiency of SPARC suppresses intestinal tumourigenesis in APCMin/+ Mice. Gut 56, 1410-4.

Clarke AR, Jones N, Pryde F, Adachi Y, Sansom OJ (2007). 53bp1 deficiency leads to polyploidy in vivo. Oncogene 26, 6349-55.

Dikovskaya D, Schiffmann D, Newton IP, Oakley A, Kroboth K, Jamieson TJ, Meniel V, Clarke A, Sansom O, Nathke IS (2007). Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol. 176, 183-95.

Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, de Alboran IM, Clevers H, Clarke AR (2006). Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc. Mol & Cell Biol. 26, 8418-26.

Prokhortchouk A, Sansom O, Selfridge J, Caballero IM, Salozhin S, Aithozhina D, Cerchietti L, Meng FG, Augenlicht LH, Mariadason JM, Hendrich B, Melnick A, Prokhortchouk E, Clarke A, Bird A (2006). Kaiso-deficient mice show resistance to intestinal cancer. Mol & Cell Biol. 26, 199-208.

Reed KR, Sansom OJ, Hayes AJ, Gescher AJ, Peters JM, Clarke AR (2006). PPARdelta status and mismatch repair mediated neoplasia in the mouse intestine. BMC Cancer 6, 113.

Sansom OJ, Meniel V, Wilkins JA, Cole AM, Oien KA, Marsh V, Jamieson TJ, Guerra C, Ashton GH, Barbacid M, Clarke AR (2006). Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. PNAS 103, 14122-7.

Serrels A, Macpherson IR, Evans TR, Lee FY, Clark EA, Sansom OJ, Ashton GH, Frame MC, Brunton VG (2006). Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Mol Cancer Ther. 5, 3014-22.

Stark LA, Reid K, Sansom OJ, Din FV, Guichard S, Mayer I, Jodrell DI, Clarke AR, Dunlop MG (2006). Aspirin activates the NF-{kappa}B signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis 28, 968-76.