Recent Publications
2011
Ahmad I, Patel R, Liu Y, Singh LB, Taketo MM, Wu XR, Leung HY, Sansom OJ (2011). Ras mutation cooperates with beta-catenin activation to drive bladder tumourigenesis. Cell Death Dis. 2, e124.
Morton JP, Myant KB, Sansom OJ (2011). A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis. Cell Cycle 10, 173-5.
Myant K, Sansom O (2011). Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex. Cell Div, 6, 3.
Ahmad I, Singh LB, Foth M, Morris CA, Taketo MM, Wu XR, Leung HY, Sansom OJ, Iwata T (2011). K-Ras and beta-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder. Dis Model Mech. 4, 548-55.
Kennedy AL, Morton JP, Manoharan I, Nelson DM, Jamieson NB, Pawlikowski JS, McBryan T, Doyle B, McKay C, Oien KA, Enders GH, Zhang R, Sansom OJ, Adams PD (2011). Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis. Mol Cell 42, 36-49.
Matthews JR, Sansom OJ, Clarke AR (2011). Absolute requirement for STAT3 function in small-intestine crypt stem cell survival. Cell Death Differ. 2011 Jun 3. [Epub ahead of print].
Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schroder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, Olson MF (2011). Actomyosin-mediated cellular tension drives increased tissue stiffness and beta-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell 19, 776-91.
Tho LM, Libertini S, Rampling R, Sansom O, Gillespie DA (2011). Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis. Oncogene 2011 Aug 1. doi: 10.1038/onc.2011.326. [Epub ahead of print].
Timpson P, McGhee EJ, Morton JP, von Kriegsheim A, Schwarz JP, Karim SA, Doyle B, Quinn JA, Carragher NO, Edward M, Olson MF, Frame MC, Brunton VG, Sansom OJ, Anderson KI (2011). Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res. 71, 747-57.
Cordero JB, Sansom OJ (2011). Wnt signalling and its role in stem cell-driven intestinal regeneration and hyperplasia. Acta Physiol (Oxf). 2011 Mar 25. [Epub ahead of print].
Morton JP, Steele CW, Sansom OJ (2011). Timing is everything: Brca2 and p53 mutations in pancreatic cancer. Gastroenterology 140, 1143-6.
Myant K, Sansom OJ (2011). More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer. Mol Cell 41, 369-70.
2010
Ahmad I, Morton J, Singh BL, Radulescu SM, Ridgway RA, Patel S, Woodgett J, D, Winton DL, Taketo MM, Wu XR Leung HY, Sansom OJ (2010). β-catenin activation synergises with PTEN loss to cause bladder cancer formation. Oncogene 30, 178-89.
Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ (2010). Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell 19, 259-69.
Athineos D, Sansom OJ (2010).
Myc heterozygosity attenuates the phenotypes of
APC deficiency in the small intestine. Oncogene
29, 2585-90.
Cole AM, Myant K, Reed KR, Athineos D, Ridgway
RA, Muncan V, Clevers H, Clarke AR, Sicinski P,
Sansom OJ (2010).
Cyclin D2-CDK4/6 is required for efficient
proliferation and tumorigenesis following Apc loss.
Cancer Res.
70, 8149-58.
Cole AM, Ridgway RA, Derkits SE, Parry L, Barker
N, Clevers H, Clarke AR, Sansom OJ (2010).
p21 loss blocks senescence following Apc loss and
provokes tumourigenesis in the renal but not the
intestinal epithelium. EMBO Mol Med. 2,
472-86.
Doyle B, Morton JP, Delaney DW, Ridgway RA,
Wilkins JA, Sansom OJ (2010).
p53 mutation and loss have different effects on
tumourigenesis in a novel mouse model of
pleomor phic rhabdomyosarcoma. J Pathol. 222,
129-37.
Morton JP, Timpson P, Karim SA, Ridgway RA, Athineos D, Doyle B,
Jamieson NB, Oien KA, Lowy AM, Brunton VG, Frame MC, Evans TRJ,
Sansom OJ (2010). Mutant p53 drives metastasis and overcomes growth
arrest/senescence in pancreatic cancer. Proc Natl Acad Sci USA 107,
246-51.
Morton JP, Jamieson NB, Karim SA, Athineos D,
Ridgway RA, Nixon C , McKay CJ, Carter R,
Brunton VG, Frame MC , Ashworth A, Oien KA,
Evans TR, Sansom OJ (2010).
LKB1 Haploinsufficiency cooperates with Kr as to
promote pancreatic cancer through suppression of
p21-dependent growth arrest. Gastroenterology 139, 586-97.
Radulescu S, Ridgway RA, Appleton P, Kroboth K,
Patel S, Woodgett J, Taylor S, Nathke IS, Sansom OJ (2010).
Defining the role of APC in the mitotic spindle
checkpoint in vivo: APC-deficient cells are resistant
to Taxol. Oncogene 29, 6418-27.
Buchert M, Athineos D, Abud HE, Burke ZD, Faux
MC, Samuel MS, Jarnicki AG, Winbanks CE,
Newton IP, Meniel VS, Suzuki H, Stacker SA, Nathke
IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Sansom
OJ, Ernst M (2010).
Genetic dissection of differential signaling threshold
requirements for the Wnt/beta-catenin pathway in
vivo. PLoS Genet. 6, e1000816.
Croft DR, Crighton D, Samuel MS, Lourenco FC, Munro J, Wood J, Bensaad K, Vousden KH, Sansom OJ, Ryan KM, Olson MF (2010). p53-mediated transcription and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival. Cell Res. 21, 666-82.
Morton JP, Karim SA, Graham K, Timpson P,
Jamieson N, Athineos D, Doyle B, McKay C, Heung
MY, Oien KA, Frame MC, Evans TR, Sansom OJ,
Brunton VG (2010).
Dasatinib inhibits the development of metastases
in a mouse model of pancreatic ductal
adenocarcinoma. Gastroenterology 139,
292-303.
Quyn AJ, Appleton PL, Carey FA, Steele RJ, Barker
N, Clevers H, Ridgway RA, Sansom OJ, Nathke IS (2010).
Spindle orientation bias in gut epithelial stem cell
compartments is lost in precancerous tissue. Cell
Stem Cell 6, 175-81.
Subauste MC, Ventura-Holman T, Lu D, Du L,
Sansom OJ, Maher JF (2010). Fem1b antigen in the stool of Apc(Min) mice as a
biomarker of early Wnt signaling activation in
intestinal neoplasia. Cancer Epidemiol. 35, 97-100.
Wolkenhauer O, Auffray C, Baltrusch S, Blüthgen N, Byrne H, Cascante M,
Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE, Jr, Gallahan D,
Gatenby R, Günther U, Harms BD, Herzel H, Junghanss C, Kunz M, van
Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK,
Malik A, Rateitschak K, Sansom O, Schäfer R, Schürrle K, Sers C,
Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R
(2010). Systems biologists seek fuller integration of systems biology
approaches in new cancer research program. Cancer Res. 70, 12-3.
Woodcock SA, Rushton HJ, Castaneda-Saucedo E,
Myant K, White GR, Blyth K, Sansom OJ, Malliri A (2010).
Tiam1-Rac signaling counteracts Eg5 during bipolar
spindle assembly to facilitate chromosome
congression. Curr Biol. 20, 669-75.
Ahmad I, Sansom OJ (2010).
Today's research: tomorrow's therapies. Future
Oncol. 6, 1095-7.
2009
Cordero J, Vidal M, Sansom O (2009). APC as a master regulator of intestinal homeostasis and transformation: From flies to vertebrates. Cell Cycle 8, 2926-31.
Ridgway RA, Athineos DA, Sansom OJ (2009). c-Myc is not essential for the skin and liver phenotypes following beta-catenin activation. Cell Cycle, in press.
Barker N, Ridgway RA, Van Es J, Clarke AR, Sansom OJ, Clevers H (2009). Intestinal stem cells as the origin of intestinal cancer. Nature 457, 608-11.
Burke ZD, Reed KR, Phesse TJ, Sansom OJ, Clarke AR, Tosh D (2009). Liver zonation occurs through a beta-catenindependent, c-Myc-independent mechanism. Gastroenterology 136, 2316-24.
Chong J-L, Wenzel PL, Saenz-Robles MT, Nair V, Ferrey A, Hagan JP, Gomez YM, Sharma N, Chen H-Z, Ouseph M, Wang S-H, Trikha P, Culp B, Mezache L, Winton DJ, Sansom OJ, Chen D, Bremner R, Cantalupo PG, Robinson ML, Pipas JM, Leone G (2009). E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells. Nature 462, 930-4.
Muller PAJ, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH (2009). Mutant p53 drives invasion by promoting integrin recycling. Cell 139, 1327-41.
Ritchie KJ, Walsh S, Sansom OJ, Henderson CJ, Wolf CR (2009). Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi. Proc Natl Acad Sci USA 106, 20859-64.
Serrels A, Serrels B, Ashton GH, Doyle BD, Frame MC, Sansom OJ, Brunton V (2009). Src inhibition slows carcinogenesis in the skin. Carcinogenesis 30, 249-57.
Shorning BY, Zabkiewicz J, McCarthy A, Pearson HB, Winton DJ, Sansom OJ, Ashworth A, Clarke AR (2009). Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS ONE 4, e4264.
Subauste MC, Sansom OJ, Porecha N, Raich N, Du L, Maher JF (2009). Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cells. Mol Carcinog. 49, 105-13.
Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, Sonntag A, Waldvogel B, Vannier C, Darling D, zur Hausen A, Brunton VG, Morton J, Sansom O, Schüler J, Stemmler MP, Herzberger C, Hopt U, Keck T, Brabletz S, Brabletz T (2009). The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nature Cell Biol. 11, 1487-95.
Stevens C, Lin Y, Harrison B, Burch L, Ridgway RA, Sansom O, Hupp T
(2009), Peptide combinatorial libraries identify TSC2 as a DAPK death
domain binding protein and reveal a stimulatory role for DAPK in mTORC1
signalling. J Biol Chem. 284, 334-44.
2008
Marsh V, Winton DJ, Williams GT, Dubois N, Trumpp A, Sansom OJ, Clarke AR (2008). PTEN is not required for intestinal stem cells but loss accelerates tumor progression. Nat Genet. 40, 1436-44.
Reed KR, Athineos DA, Meniel VS, Wilkins JA, Ridgway RA, Muncan V, Clarke AR, Sansom OJ (2008). Beta-catenin and not c-Myc rescues the phenotypes of Apc loss in the liver. PNAS 105, 18919-23.
Phesse TJ, Parry L, Reed KR, Ewan KB, Dale TC, Sansom OJ, Clarke AR (2008). Deficiency of Mbd2 attenuates Wnt signalling. Mol Cell Biol. 19, 6094-103.
Patek CE, Arends MJ, Rose L, Luo F, Walker M, Devenney PS, Berry RL, Lawrence NJ, Ridgway RA, Sansom OJ, Hooper ML (2008). The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine. BMC Gastroenterol. 8, 24.
Reed KR, Meniel VS, Marsh V, Cole A, Sansom OJ, Clarke AR (2008). A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer 5, 162.
2007
Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR (2007). c-Myc deletion rescues Apc deficiency in the small intestine. Nature 446, 676-9.
Patek CE, Arends MJ, Wallace WA, Luo F, Hagan S, Brownstein DG, Rose L, Devenney PS, Walker M, Plowman SJ, Berry RL, Kolch W, Sansom OJ, Harrison DJ, Hooper ML (2008). Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis. Exp Cell Res. 314, 1105-14.
Berger J, Sansom OJ, Clarke AR, Bird A (2007). MBD2 is required for correct spatial gene expression in the gut. Mol Cell Biol. 27, 4049-57.
Sansom OJ, Mansergh F, Evans M, Wilkins JA, Clarke AR (2007). Deficiency of SPARC suppresses intestinal tumourigenesis in APCMin/+ Mice. Gut 56, 1410-4.
Clarke AR, Jones N, Pryde F, Adachi Y, Sansom OJ (2007). 53bp1 deficiency leads to polyploidy in vivo. Oncogene 26, 6349-55.
Dikovskaya D, Schiffmann D, Newton IP, Oakley A, Kroboth K, Jamieson TJ, Meniel V, Clarke A, Sansom O, Nathke IS (2007). Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J Cell Biol. 176, 183-95.
Colorectal cancer is the third most common cancer in the UK and the second most common cause of cancer mortality. 
Scientific Report 2010 Sansom (
