Lab Report
Scientific Report 2010 White (130.99 kB)
Key Publications
Marshall L, White RJ (2008). Non-coding RNA production by RNA polymerase III is implicated in cancer. Nature Rev. Cancer 8, 911-914.
Marshall L, Kenneth NS, White R J. (2008). Elevated tRNA
iMet synthesis can drive cell proliferation and oncogenic transformation. Cell 133, 78-89.
Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ. (2005). c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nature Cell Biol. 7, 311-318.
Gomez-Roman N, Grandori C, Eisenman RN, White RJ.(2003). Direct activation of RNA polymerase III transcription by c-Myc. Nature 421, 290-294.
White RJ, Trouche D, Martin K, Jackson SP, Kouzarides T. (1996). Repression of RNA polymerase III transcription by the retinoblastoma protein. Nature 382, 88-90.
Biography
Education and qualifications
1990: PhD, University of London (National Institute for Medical Research), Supervisor Peter Rigby
1986: BA, Biochemistry (First Class Honours), University of Oxford
Appointments
2006-present: Group Leader, Beatson Institute for Cancer Research, Glasgow
1999-present: Professor of Gene Transcription, Institute of Biomedical and Life Sciences, University of Glasgow
1996-2001: Jenner Research Fellow, Lister Institute of Preventive Medicine
1995-1999: Lecturer, Institute of Biomedical and Life Sciences, University of Glasgow
1991-1995: Postdoctoral Research Assistant with Stephen P. Jackson, Wellcome/CRC Institute, University of Cambridge
1990-1991: Postdoctoral Research Assistant with Robert A. H. White, Anatomy Dept, University of Cambridge
Honours and Awards
Elected a Member of the European Molecular Biology Organization, 2009
Elected Fellow of the Academy of Medical Sciences, 2005
Tenovus Medal, 2004
Elected Fellow of the Royal Society of Edinburgh, 2004
Young Cancer Researcher Award, European Association for Cancer Research, 2003
Young Scientist Award, British Association for Cancer Research, 1999
Jenner Fellowship, Lister Institute of Preventive Medicine, 1996
Recent Publications
2011
White RJ (2011). Transcription by RNA polymerase III - more complex than we thought. Nature Rev Genet. 12, 459-63.
Ebersole T, Kim JH, Samoshkin A, Kouprina N, Pavlicek A, White RJ, Larionov V (2011). tRNA genes protect a reporter gene from epigenetic silencing in mouse cells. Cell Cycle 2011 Aug 15;10(16). [Epub ahead of print].
Roman AC, Gonzalez-Rico FJ, Molto E, Hernando H, Neto A, Vicente C, Ballestar E, Gomez-Skarmeta JL, Vavrova J, White RJ, Montoliu L, Fernandez-Salguero PM (2011). Dioxin receptor and Slug transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch. Genome Res. 21, 422-32.
2010
Owen TJ, O'Neil JD, Dawson CW, Hu C, Chen X, Yao Y, Wood VHJ, Mitchell LE, White RJ, Young LS, Arrand JR (2010). Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III- dependent EBER expression through induction of EBER-associated cellular transcription factors. Mol Cancer 9, 241.
Kantidakis T, White RJ (2010). Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells. Nucleic Acids Res. 38, 1228-39.
Athineos D, Marshall L, White RJ (2010). Regulation of TFIIIB during F9 cell differentiation. BMC Mol Biol. 11, 21.
White RJ, Sharrocks AD (2010). Coordinated control of the gene expression machinery. Trends Genet. 26, 214-20.
Barski A, Chepelev I, Liko D, Cuddapah S, Fleming AB, Birch J, Cui K, White RJ, Zhao K (2010). Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes. Nat Struct Mol Biol. 17, 629-34.
Moqtaderi Z, Wang J, Raha D, White RJ, Snyder M, Weng Z, Struhl K (2010). Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells. Nat Struct Mol Biol. 17, 635-40.
Kantidakis T, Ramsbottom BA, Birch JL, Dowding SN, White RJ (2010). mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. Proc Natl Acad Sci U S A. 107, 11823-8.
Kantidakis T, White RJ (2010). A feedback loop between mTOR and tRNA expression? Cell Cycle 9, 2934-5.
2009
Kenneth NS, White RJ (2009). Regulation by c-Myc of ncRNA expression. Curr Opin Genet Dev. 19, 38-43.
2008
Marshall L, White RJ (2008). Non-coding RNA production by RNA polymerase III is implicated in cancer. Nature Rev. Cancer 8, 911-914.
White RJ (2008). RNA polymerases I and III, non-coding RNAs and cancer. Trends Genet. 24, 622-629.
Angelis E, Garcia A, Chan SS, Schenke-Layland S, Ren K, Goodfellow SJ, Jordan MC, Roos KP, White RJ, MacLellan WR (2008). A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium. Circulation Res. 102, 1222-1229.
Goodfellow SJ, Graham EL, Kantidakis T, Marshall L, Coppins BA, Oficjalska-Pham D, Gerard M, Lefebvre O, White RJ (2008). Regulation of RNA polymerase III transcription by Maf1 in mammalian cells. J Mol Biol. 378, 481-491.
Marshall L (2008). Elevated RNA polymerase III transcription drives proliferation and oncogenic transformation. Cell Cycle 7, 3327-3329.
Kenneth NS, Marshall L, White RJ (2008). Recruitment of RNA polymerase III in vivo. Nucleic Acids Res. 36, 3757-3764.
Marshall L, Kenneth NS, White R J. (2008). Elevated tRNA
iMet synthesis can drive cell proliferation and oncogenic transformation. Cell 133, 78-89.
2007
Kenneth NS, Ramsbottom BA, Gomez-Roman N, Marshall L, Cole PA, White RJ (2007). TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. Proc Natl Acad Sci USA 104, 14917-22.
Marshall L, Goodfellow SJ,White RJ (2007). Diminished activity of RNA polymerase III selectively disrupts tissues with the most actively dividing cells. PLoS Biol. 5, e286.
Morton JP, Kantidakis T,White RJ (2007). RNA polymerase III transcription is repressed in response to the tumour suppressor ARF. Nucleic Acids Res. 35, 3046-52.
Goodfellow SJ,White RJ (2007). Regulation of RNA polymerase III transcription during mammalian cell growth. Cell Cycle 6, 2323-26.
Transcription by RNA polymerases (pols) I and III is often abnormal in tumours. These pols make rRNA and tRNA, which provide about 95% of a cell’s RNA content. 
