Link to White Scientific Report 2008 148.67 Kb

Key Publications

Marshall L, Kenneth NS, White R J. (2008). Elevated tRNAiMet synthesis can drive cell proliferation and oncogenic transformation. Cell 133, 78-89.

Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ. (2005). c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nature Cell Biol. 7, 311-318.

White RJ. (2005). RNA polymerases I and III, growth control and cancer. Nature Rev. Mol Cell Biol. 6, 69-78.

Gomez-Roman N, Grandori C, Eisenman RN, White RJ.(2003). Direct activation of RNA polymerase III transcription by c-Myc. Nature 421, 290-294.

White RJ, Trouche D, Martin K, Jackson SP, Kouzarides T. (1996). Repression of RNA polymerase III transcription by the retinoblastoma protein. Nature 382, 88-90.

Education and qualifications
1990: PhD, University of London (National Institute for Medical Research), Supervisor Peter Rigby
1986: BA, Biochemistry (First Class Honours), University of Oxford

Appointments
2006-present: Group Leader, Beatson Institute for Cancer Research, Glasgow
1999-present: Professor of Gene Transcription, Institute of Biomedical and Life Sciences, University of Glasgow
1996-2001: Jenner Research Fellow, Lister Institute of Preventive Medicine
1995-1999: Lecturer, Institute of Biomedical and Life Sciences, University of Glasgow
1991-1995: Postdoctoral Research Assistant with Stephen P. Jackson, Wellcome/CRC Institute, University of Cambridge
1990-1991: Postdoctoral Research Assistant with Robert A. H. White, Anatomy Dept, University of Cambridge

Honours and Awards
Elected Fellow of the Academy of Medical Sciences, 2005
Tenovus Medal, 2004
Elected Fellow of the Royal Society of Edinburgh, 2004
Young Cancer Researcher Award, European Association for Cancer Research, 2003
Young Scientist Award, British Association for Cancer Research, 1999
Jenner Fellowship, Lister Institute of Preventive Medicine, 1996

Marshall L, White RJ (2008). Non-coding RNA production by RNA polymerase III is implicated in cancer. Nature Rev. Cancer 8, 911-914.

White RJ (2008). RNA polymerases I and III, non-coding RNAs and cancer. Trends Genet. 24, 622-629.

Angelis E, Garcia A, Chan SS, Schenke-Layland S, Ren K, Goodfellow SJ, Jordan MC, Roos KP, White RJ, MacLellan WR (2008). A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium. Circulation Res. 102, 1222-1229.

Goodfellow SJ, Graham EL, Kantidakis T, Marshall L, Coppins BA, Oficjalska-Pham D, Gerard M, Lefebvre O, White RJ (2008). Regulation of RNA polymerase III transcription by Maf1 in mammalian cells. J Mol Biol. 378, 481-491.

Marshall L (2008). Elevated RNA polymerase III transcription drives proliferation and oncogenic transformation. Cell Cycle 7, 3327-3329.

Kenneth NS, Marshall L, White RJ (2008). Recruitment of RNA polymerase III in vivo. Nucleic Acids Res. 36, 3757-3764.

Marshall L, Kenneth NS, White R J. (2008). Elevated tRNAiMet synthesis can drive cell proliferation and oncogenic transformation. Cell 133, 78-89.

Kenneth NS, Ramsbottom BA, Gomez-Roman N, Marshall L, Cole PA, White RJ (2007). TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. Proc Natl Acad Sci USA 104, 14917-22.

Marshall L, Goodfellow SJ,White RJ (2007). Diminished activity of RNA polymerase III selectively disrupts tissues with the most actively dividing cells. PLoS Biol. 5, e286.

Morton JP, Kantidakis T,White RJ (2007). RNA polymerase III transcription is repressed in response to the tumour suppressor ARF. Nucleic Acids Res. 35, 3046-52.

Goodfellow SJ,White RJ (2007). Regulation of RNA polymerase III transcription during mammalian cell growth. Cell Cycle 6, 2323-26.

Felton-Edkins ZA, Kondrashov A, Karali D, Fairley JA, Dawson CW, Arrand JR, Young LS, White RJ (2006). Epstein-Barr virus induces cellular transcription factors to allow active expression of EBER genes by RNA polymerase III. J Biol Chem. 281, 33871-80.

Goodfellow SJ, Innes F, Derblay LE, MacLellan WR, Scott PH,White RJ (2006). Regulation of RNA polymerase III transcription during hypertrophic growth. EMBO J. 25, 1522-33.

Innes F, Ramsbottom B, White RJ (2006). A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC. Nucleic Acids Res. 34, 3399-407.

Gomez-Roman N, Felton-Edkins ZA, Kenneth NS, Goodfellow SJ, Athineos D, Zhang J, Ramsbottom BA, Innes F, Kantidakis T, Kerr ER, Brodie J, Grandori C, White RJ (2006). Activation by c-Myc of transcription by RNA polymerases I, II and III. Biochem Soc Symposia 73, 141-54.

Ernens I, Goodfellow SJ, Innes F, Kenneth NS, Derblay LE, White RJ, Scott PH (2006). Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes. Nucleic Acids Res. 34, 286-94.