TRACC Programme CRTF-PhD

Clinical Research Training Fellowships with PhD

Call for applications is now open!

Applications should be submitted, along with a supporting statement outlining your motivations for joining this programme (up to 300 words) and full CV, using the University's online application system.
To apply, visit the University of Glasgow's Jobs page and search for vacancy reference 043804. Closing date: 18 December 2020, 5pm. Interview date: 15 January 2020.

Potential projects for 2021 intake

  • The use of patient-derived rectal cancer organoids to develop and validate novel radiotherapy-based treatment strategies - Campbell Roxburgh, Glasgow and Kevin Myant, Edinburgh
  • Investigating the roles for NF-kB in inflammation-associated colorectal cancer - Chengcan Yao, Edinburgh and Owen Sansom, Glasgow
  • Exploring the value of epigenetic modifications as modulators of drug response in CCA - Chiara Braconi, Glasgow and Luke Boulter, Edinburgh
  • Reverse translation from ex-vivo to in-vivo models to identify novel therapeutic avenues in cholangiocarcinoma -Chiara Braconi, Glasgow and Luke Boulter, Edinburgh
  • Targeting Autophagy to Prevent Childhood ALL Relapse in the Central Nervous System - Chris Halsey and Vignir Helgason, Glasgow
  • Predicting and investigating radiotherapy (RT) resistance in poor prognosis head and neck squamous cell cancer (HNSCC) - Claire Paterson, Glasgow and Bill Nailon, Edinburgh
  • Optimising immunotherapies in metastatic colorectal cancer - Colin Steele and Leo Carlin, Glasgow
  • Mechanisms of resistance to checkpoint inhibition in KRAS-driven lung cancer - Daniel Murphy, Glasgow and Calum Bain, Edinburgh
  • A patient-derived organoid pipeline for identifying therapeutic vulnerabilities in biliary cancers using live-imaging, machine learning, and drug repurposing - Dave Bryant and Chaira Braconi, Glasgow
  • Investigating the relationship between regional tumour metabolism and treatment resistance in glioblastoma multiforme (GBM) - David Lewis, Glasgow and Gerard Thompson, Edinburgh
  • Effects of exercise on human colorectal normal epithelium transcriptome and methylome - Farhat Din and Kevin Myant, Edinburgh
  • Using human and drosophila models to investigate the role of intestinal enteroendocrine cells in colorectal cancer- Farhat Din and Kevin Myant, Edinburgh
  • The role of B7-H3 immune regulatory molecule in prostate carcinogenesis - Hing Leung and Carl Goodyear, Glasgow
  • The role of Transcription Elongation Factor A Like 1 in prostate cancer and treatment response - Hing Leung, Glasgow and Bin-Zhi Qian, Edinburgh
  • Alternative splicing in pancreatic cancer - Jen Morton and David Chang, Glasgow
  • Molecular characterisation of the colonic mucosa as a determinant of future colorectal neoplasia risk - Joanne Edwards, Glasgow and Ian Tomlinson, Edinburgh
  • Unravelling genomic and epigenetic determinants of tumour cell behaviour and virulence by machine learning - John Le Quesne and Martin Bushell, Glasgow
  • Deciphering the role of the PIWI pathway in colorectal cancer - Julia Cordero, Glasgow and Farhat Din, Edinburgh
  • Investigating epigenetic therapies and chemo-resistance in paediatric AML - Karen Keeshan and David Vetrie, Glasgow
  • Replacing IFNA as a therapeutic strategy in GBM - Kathryn Ball and Paul Brennan, Edinburgh
  • Defining the function of TGF-β signalling in colorectal cancer metastasis - Kevin Myant, Edinburgh and Colin Steele, Glasgow
  • Modelling the liver metastatic niche with human iPSC derived liver spheroids and invasive cancer cells - Laura Machesky, Glasgow and David Hay, Edinburgh
  • Exploring the role of the bone marrow niche in progression of myeloproliferative neoplasms - Mhairi Copland, Glasgow and Elaine Dzierzak, Edinburgh
  • Dissecting spatial tumour heterogeneity in pancreatic cancer - Nigel Jamieson, Glasgow and Peter Bankhead, Edinburgh
  • Targeting therapeutic resistance in colorectal cancer - Owen Sansom, Glasgow and Simon Barry, AZ
  • Immunological consequences of mtDNA mutations in colorectal cancer - Payam Gammage and Ed Roberts, Glasgow
  • Efficient clinical pathway design combining NHS data, molecular profiling and clinical trials - Peter Hall, Edinburgh and Iain MacPherson, Glasgow
  • Using deep learning in cancer pathology to infer markers without new staining - Rob Insall, Glasgow and Peter Bankhead, Edinburgh
  • Integrated Approach to Developing New Treatments for Colorectal Cancer - Ross Cagan, Glasgow and Ian Tomlinson, Edinburgh
  • NRF2 as a biomarker of radioresistance in locally advanced rectal cancer - Sean O'Cathail and Joanne Edwards, Glasgow
  • Investigating a new type of radioimmunotherapy to improve glioblastoma treatment - Stephen Tait, Glasgow and Noor Gammoh, Edinburgh
  • Zonal heterogeneity in liver cancer formation and regeneration - Tom Bird, Glasgow and Neil Henderson, Edinburgh
  • Zonal heterogeneity in liver cancer and regeneration - Tom Bird, Glasgow and Neil Henderson, Edinburgh
  • Identification of new therapeutic approaches for undifferentiated pleomorphic sarcoma - Valerie Brunton and Donald Salter, Edinburgh
  • Single Cell Mapping and Visualisation of Immune Cell Subpopulations in the Leukaemic Niche - Vignir Helgason, Glasgow and Elaine Dzierzak, Edinburgh
  • High Throughput Phenotypic Screen using a whole animal model to identify novel cancer prevention drugs - Yi Feng and Neil Carragher, Edinburgh

The TRACC Programme Clinical Research Training Fellowships (CRTFs) enable clinicians who have already completed their medical degree to develop an academic career and obtain a PhD degree. This is done in parallel to their core activities in the clinic and achieved through flexible Clinical Lectureships and personalised mentoring by experienced Clinical Academics.

d tracc-crtf-phd-programme

Scheme Summary

The selection of clinical research training fellows and their matching to supervisors/projects will be via a joint Glasgow-Edinburgh selection panel and will be based on established good practice from both partners. The appointed fellows will participate in an induction week, visiting both Edinburgh and Glasgow with structured networking with potential PhD supervisors from both institutions and to match with their clinical and research mentors (see the figure below). The fellows will choose their base location in Glasgow or Edinburgh and register for a PhD at the University of Glasgow or the University of Edinburgh respectively. Postgraduate Deans at both Universities have agreed to provide Clinical Lectureships to facilitate these arrangements. During their pre-doctoral appointment and the PhD period the fellows will be advised and supported through a carefully designed monitoring and mentoring scheme. On appointment each trainee will be allocated a Clinical Mentor, an academically-active clinician from a relevant discipline, who will assist with integrating clinical and research training.

e crtfActivities during one-year 'run-in' period of the TRACC clinical research training fellowship. OOPR stands for Out of Programme Research

Eligibility and application procedure

  • Applications are welcomed from trainees in all specialties and from all regions of the UK.
  • All applicants must hold a medical degree.

Essential attributes

  • Aspiring to PhD training that is relevant to cancer.
  • Eligible for higher clinical training.
  • Hold a National Training Number at the time of application or be in the process of applying for one to be in place for the relevant start date.
  • Evidence of high academic distinction and potential (first class honours BSc, honours MBChB, multiple prizes, research papers, etc.).
  • Introductory research experience at BSc or MSc, undergraduate research project, postgraduate research with high attainment.
  • Of a standard likely to be successful in obtaining a Training Fellowship in national open competition.

Application procedure

Recruitment takes place in the autumn for intake in the following August. Vacancies will be advertised via multiple outlets including the following websites:

University's vacancies' web pages
BMJ
jobs.ac.uk

Relevant information will be also provided on this website and the mirror site at the CRUK Edinburgh Centre.

Applications should be submitted, along with a supporting statement outlining your motivations for joining this programme (up to 300 words) and full CV, using the University's online application system. All applicants will be notified if they have been shortlisted for interview or not. Shortlisted candidates will be invited for an interview in front of a panel including members of the TRACC Programme Management Board and invited external panel members. All shortlisted candidates will be notified if they have been successful at interview or not.

Questions about the recruitment procedure and entry requirements are welcomed and should be directed to the administrator of the TRACC Programme CRTF scheme (j.beesley@beatson.gla.ac.uk).

Research

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Read more about the Research Groups working at the Beatson Institute.

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Seminars

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Find out more about our seminars including our Distinguished Seminar Programme.

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