Dr Julia Cordero - Local and Systemic Functions of the Intestine in Health and Disease
The adult intestine is a major barrier epithelium with vital endocrine, immune and metabolic roles, leading to the coordination of whole-body physiology. These functions are achieved by specialised cells such as absorptive enterocytes and secretory enteroendocrine cells, which are generated by intestinal stem cells (ISCs). Stem cells constantly repair the intestinal epithelium by adjusting their proliferation and differentiation to tissue intrinsic as well as micro- and macro-environmental signals. How do these signals integrate to preserve intestinal and whole-body health?
Work in our laboratory is devoted to deciphering the cellular and molecular mechanisms regulating ISC behaviour during tissue regeneration and tumourigenesis. We are also interested in understanding how the intestine interacts with other tissues and organs to maintain organismal balance and how these interactions are deregulated in intestinal diseases such as cancer or inflammation. We use the fruit fly Drosophila melanogaster as our primary in vivo research model system combined with suitable mammalian paradigms.
Our research aims to identify mechanisms that could be used in translational efforts to restore intestinal regeneration as well as to prevent malignant transformation of the intestine and alleviate the systemic consequences of intestinal malfunction.
Education and qualifications
2007. Ph.D. degree in the Molecular Cell Biology Program, Washington University School of Medicine. Saint Louis, MO, USA. Thesis Advisor: Dr. Ross L. Cagan
1999: “Licenciada en Biología Molecular”, San Luis National University. San Luis, Argentina.
2016-present: Senior Research Fellow, Institute of Cancer Sciences, University of Glasgow.
2016-present: Honorary Group Leader, Cancer Research UK Beatson Institute, Glasgow.
2016-Present: Senior Research Fellow. Wolfson Wohl Cancer Research Centre. Institute of Cancer Sciences, University of Glasgow.
2016-Present: Honorary Group Leader, Cancer Research UK Beatson Institute
2014-2016. Junior Research Fellow. Wolfson Wohl Cancer Research Centre. Institute of
Cancer Sciences. University of Glasgow. Glasgow, United Kingdom.
2009-2014: Postdoctoral Fellow, Cancer Research UK Beatson Institute
2007-2008: Post-doctoral Fellow, Mount Sinai School of Medicine New York, NY. USA
2000-2002: Research Assistant, Department of Internal Medicine, Renal Division, Washington University School of Medicine, Saint Louis, MO, USA.
Perochon, J., Aughey, G.N., Southall, T.D., and Cordero, J.B. Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis. bioRxiv, 2021. doi: https://doi.org/10.1101/2021.01.10.426079
Naszai, M., Yu, Y., Fernandez, A.R., Sandilands, E., Johansson, J., Norman, J.C., Sansom, O.J., Bryant, D., and Cordero, J.B. RAL GTPases mediate EGFR/MAPK signalling-driven intestinal stem cell proliferation and tumourigenesis upstream of RAS activation. bioRxiv, 2020. doi: https://doi.org/10.1101/2020.10.07.329607
Bellec K, Cordero JB. The Peroxisome: A New Player in Intestinal Epithelial Repair. Dev Cell. 2020;53:131-132.
Johansson J, Naszai M, Hodder M, Pickering K, Miller BW, Ridgway RA, Yu Y, Peschard P, Brachmann B, Campbell AD, Cordero, JB1, Sansom, OJ. RAL GTPases drive intestinal stem cell function and regeneration through internalization of WNT signalosomes. Cell Stem Cell. Apr 4;24(4):592-607.e7. Commentary in Cell Stem Cell 2019 Apr 4;24:499-500.
Parvy JP1, Yu Y, Dostalova A, Kondo S, Kurjan A, Bulet P, Lemaitre B, Vidal M, Cordero JB. The antimicrobial peptide Defensin cooperates with Tumour Necrosis Factor to drive tumour cell death in Drosophila. Elife. 2019 Jul 30;8. pii: e45061. doi: 10.7554/eLife.45061. Recommended by the Faculty of 1000.
Scopelliti A, Bauer C, Yu Y, Zhang T, Krüspig B, Murphy DJ, Vidal M, Maddocks OK, Cordero JB. A neuronal relay mediates a nutrient responsive gut/fat body axis regulating energy homeostasis in adult Drosophila. Cell Metab. 2019 Feb 5;29:269-284.e10.
Parvy JP, Hodgson JA, Cordero JB. Drosophila as a Model System to Study Nonautonomous Mechanisms Affecting Tumour Growth and Cell Death. Biomed Res Int. 2018:7152962.
Perochon J, Carroll LR, Cordero JB. Wnt Signalling in Intestinal Stem Cells: Lessons from Mice and Flies. Genes (Basel). 2018;9. pii: E138.
Tian A, Benchabane H, Wang Z, Zimmerman C, Xin N, Perochon J, Kalna G, Sansom OJ, Cheng C, Cordero JB, Ahmed Y. Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing. PLoS Genet. 2017 Jul 14;13:e1006870.
Scopelliti A, Bauer C, Cordero J and Vidal M. Bursicon-α subunit modulates dLGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-β. Cell Cycle. 2016;15:1538-44.
Elbediwy A, Vincent-Mistiaen ZI, Spencer-Dene B, Stone RK, Boeing S, Wculek SK, Cordero J, Tan EH, Ridgway R, Brunton VG, Sahai E, Gerhardt H, Behrens A, Malanchi I, Sansom OJ, Thompson BJ. Integrin signalling regulates YAP and TAZ to control skin homeostasis. Development. 2016;143:1674-87.
Jessica Perochon (Wellcome Trust)