The TransPot scientific aim is to obtain an unmatched depth of understanding of prostate cancer in order to improve the prognosis and treatment of lethal prostate cancer. This will include:
• Providing important insights into the mechanisms driving treatment resistant prostate cancer (including CRPC);
• Identifying novel targets for therapy;
• Developing and validating predictive models for disease progression and prognosis;
• Providing superior, clinically relevant tools and biomarkers for personalising and optimising CRPC therapy.
The TransPot project will incorporate the latest research technologies to understand lethal prostate cancer, and the network has been assembled to include leading academic and non-academic researchers, together giving an unrivalled expertise in the field. It will offer an innovative training programme for early stage researchers (ESRs) to ensure that they can effectively operate in today's multi-disciplinary programmes in scientific research. The training will include both scientific and transferable skill sets. Additionally, the network will focus on promoting their research to the whole of society to raise awareness and understanding of PC. This will include events such as open days and outreach events to schools, as well as communicating research advances and results via the media and social media. Advances achieved will facilitate personalised targeted medicine in treating lethal PC, and will impact beyond the scientific community by improving the well-being of advanced PC patients.
The central aim of TransPot is to provide a multi-disciplinary research training programme integrating cancer biology and systems medicine to train young researchers to become future successful leaders in cancer research. It will provide ESRs with a solid base for a career in translational research in either academia or industry. For this purpose, our programme consists of individual (interconnected) research projects. Supplementing these projects is a broad range of network-wide training activities including:
• Local training activities: PhD programme activities at host institute, local seminars and public engagement activities;
• Network-wide events: meetings, annual training events (see table below);
• Secondments: research-focused study visits to other labs (both academic and industrial) within the consortium of 1-2 months duration in order to gain specific skills sets;
• International conferences, peer-reviewed publications and thesis preparation.
Our ESRs will benefit from both generic and specific research skills, many of which are transferable, incorporating a wide range of topics: cancer biology, novel PC models, high-content screening, mathematical and computational modelling, as well as generic skills including intellectual property, gender issues, research integrity, entrepreneurship, communication and management.
This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 721746