Ed Roberts was co-first author on a paper with colleagues from UCSF in Cancer Cell (Visualizing synaptic transfer of tumor antigens among dendritic cells), which describes how dendritic cells (DCs) transport tumour antigens to the lymph node within vesicles, which they then transfer to other resident DCs. Only DCs containing these vesicles can then activate T cells, which go on to infiltrate the tumour. Understanding these early steps in the development of anti-tumour immunity could ultimately lead to better treatments for cancer.
Emily Kay, Sara Zanivan and co-authors made a preprint available on bioRxiv (Metabolic control of tumour extracellular matrix production in cancer-associated fibroblasts), which finds that extracellular matrix production by cancer-associated fibroblasts - which is pro-tumorigenic - is under strict metabolic control, in particular as a result of increased proline synthesis.
Daniel Murphy and colleagues also had a preprint in bioRxiv (Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma), which shows that asbestos-driven inflammation contributes to mesothelioma in a genetically modified mouse model. This model system could assist in finding better ways to tackle this challenging lung cancer, which has its highest incidence in Glasgow.
Matthias Pietzke, Alexei Vazquez and colleagues at the Beatson and in Cambridge investigated amino acid dependent formaldehyde metabolism in mammalian cells in a paper in Communications Chemistry.
The Beatson is extremely proud of all of our scientists who are volunteering in the Lighthouse Lab testing centre in Glasgow and supporting efforts to tackle COVID-19. Here is a round up of some of their stories, which you can currently find in the Scottish press:
Grant McGregor's story ran in The Courier on 12th June: https://www.thecourier.co.uk/fp/news/local/fife/1367726/fife-cancer-scientist-switches-to-coronavirus-testing-effort/ and the Central Fife Times: https://www.centralfifetimes.com/news/18518592.dr-grant-mcgregor-helped-set-test-facility-record-time/
Jo Birch featured in the Stirling Observer, and also on the Daily Record website: https://www.dailyrecord.co.uk/news/balfron-scientist-jo-steps-up-22181868
Lynn McGarry was on the front page of that Paisley Daily Express, and also on the Daily Record website: https://www.dailyrecord.co.uk/news/local-news/paisley-cancer-research-scientist-joins-22193081
Grant, Lynn and Natasha Malik also featured on the Glasgow Times website: https://www.glasgowtimes.co.uk/news/18523307.glasgow-cancer-scientists-using-skills-fight-coronavirus/
Dr Dave Bryant, one of our scientists here at the Beatson, is doing all he can to support Cancer Research UK's Race For Life At Home. He is encouraging everyone to take part in a challenge at home to raise vital funds for life-saving cancer research. But he and his husband, Zachary Claudino have also set themselves a Race For Life At Home challenge of their own, to run for 30 minutes every day together during their daily exercise with their pet dog, Lucy.
Dave, Zach and Lucy the dog
As part of his research at the Institiute, Dave and his team of scientists are building prostate, ovarian and bowel cancer 'avatars': 3D models of cancer cells that they can study using time-lapse microscopy to find out how they move and spread. Dave explains: "We use AI techniques to analyse the patterns of cancer cell spread. Then we can genetically alter the cancer cells to identify which genes cause them to spread. Our hope is that this information could help us find and test drugs that could stop cancer from spreading."
More details of how to take part in Race For Life At Home can be found here.
Dave's story also appeared in the Glasgow Evening Times: https://www.glasgowtimes.co.uk/news/18437182.proud-glasgow-australian-cancer-scientist-using-ai-hunt-cure-beatson/
BBC News has been inside the new Glasgow Lighthouse Lab, a collaboration between the University of Glasgow, the private sector, the Cancer Research UK Beatson Institute and the NHS. Several researchers from the Beatson as well as colleagues from the Institute of Cancer Sciences are volunteering in lab, including Jo Birch, Jodie Hay, Nati Gomez-Roman, Grant McGregor, Lynn McGarry and Natasha Malik.
Grant, Lynn and Natasha are pictured here in the lab in their protective gear:
It was announced today (22 April 2020) that a major new COVID-19 testing facility, the Lighthouse Laboratory in Glasgow, has opened in collaboration with the Cancer Research UK Beatson Institute.
The Lighthouse Laboratory is funded by the UK Government and hosted by the University of Glasgow at its campus at the Queen Elizabeth University Hospital. Around a quarter of the scientist volunteers who will carry out COVID-19 tests are from the CRUK Beatson Institute. As well as the volunteers, the Institute has donated kit to set up the Glasgow testing facility, including four PCR machines and vital reagents.
In response to today's announcement, Professor Owen Sansom, Director of the CRUK Beatson Institute, said:
"I am incredibly proud of all our staff and scientists from the Cancer Research UK Beatson Institute who have volunteered to put their expert skills and talent to use at the Glasgow Lighthouse Laboratory to help our NHS colleagues and the COVID-19 response. Just like cancer research, this fight is about everyone working together to make a difference. Cancer won't be going away during or after COVID-19 but, by helping the global effort to tackle the virus, we hope we can get back to beating cancer as soon as possible."
The University of Glasgow has announced it will host a major COVID-19 testing centre at its Clinical Innovation Zone at the Queen Elizabeth University Hospital campus in Glasgow as part of efforts to combat the pandemic [see BBC News 2 April 2020]. The Cancer Research UK Beatson Institute has been playing its part, in partnership with the University, to get the laboratory up and running by donating PCR machines and vital reagents, and several Institute staff members will be volunteering their time and expertise once testing begins in mid-April.
Institute Director, Owen Sansom said: "I couldn't be more pleased for the Cancer Research UK Beatson Institute to be helping NHS colleagues in this way, as well as the local community which has been so supportive of the Institute's work over many years. Just as with cancer research, this fight is about everyone working together to make a difference."