Postdoctoral Research Scientist - Prof John Le Quesne

Beatson Lab: Deep Phenotyping of Solid Tumours

Project Title: Epithelial plasticity and virulence in lung adenocarcinoma

Salary: from £32,868 to £42,717 subject to experience, plus relocation allowance and visa costs if required.

Contract term: Fixed up to 6 years, subject to successful review at Year 3


About us

The CRUK Beatson Institute where the lab is based is a world leading cancer research institute, situated in the vibrant city of Glasgow in Scotland and hosting approximately 60 postdoctoral researcher scientists at any one time. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned in vivo modelling of tumour growth and metastasis.

Project outline

A postdoctoral position is offered in the Deep Phenotyping group headed by Professor John Le Quesne. As a group we apply the latest in quantitative image-forming pathological and molecular methods to human and model tissues to understand how tumours function at the cellular level.

The project addresses a key question in solid tumour biology; what is the significance of epithelial plasticity, and how does it influence the clinicopathological tumour behaviour? We find that phenotypic plasticity underlies the most lethal morphologies in lung adenocarcinoma; how does this drive hallmark tumour behaviour such as metastasis?

We house and use the very latest in quantitative multiplex imaging and spatial transcriptomic technologies, and apply them to large cohorts of archival human mouse model tumour tissues. The successful applicant will work with data generated by our own expert technical team, by our core facilities, and with collaborators. You will use this data to answer a range of key questions about tumour cell plasticity, and there is potential both for clinical translation and in vivo modelling.

You must have a PhD in a relevant field, be ambitious, and driven by scientific curiosity. Exisiting skills with regard to digital pathology, quantitative image analysis (eg QuPath, visiopharm) and bioinformatic methods are all desirable.

To find out more about this unique opportunity to establish advanced skills and expertise in this exciting field please contact: Professor John Le Quesne,

Postdoc support

Postdocs are key members of our research community, and we offer them a range of opportunities to train and develop as researchers while they are with us:

  • Exciting, innovative cancer research projects in state-of-the art labs
  • A highly collaborative and interactive research environment
  • Access to and training in key advanced technologies, for example imaging and in vivo modelling
  • A mentor enabling scheme to aid personal and professional development
  • A rich programme of scientific exchange through seminars, workshops and meetings
  • Support to make fellowship and small grant applications, including during their transition to their next position
  • Guidance and mentoring to compete for an independent scientist position as well as a multitude of other career options, including in industry.
  • A highly engaged postdoc forum, providing peer support, training, careers advice and regular social events

Equality, Diversity and Inclusion

Our overarching research ethos at the Institute is about excellence, honesty, openness, accountability and integrity. The diversity of our staff and students is also what makes the Institute such a vibrant place to work and advance discoveries in cancer research. Family friendly policies, our collaborative ethos, a focus on good mental health and well-being and opportunities for all help to create an enjoyable and inclusive workplace where your voice matters.

The Institute is also committed to increasing the number of female scientists at the postdoc level and beyond and encourages female applicants to apply. We have a highly attractive maternity policy which provides 12-18 months support and funding for postdocs wishing to take time off to spend with their children amongst other family friendly policies.


Closing Date for Applications: 28 October 2022 but we will contact promising candidates on a rolling basis, so please apply as soon as you are ready.


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