Beatson Lab: Liver disease and regeneration
Project Title: Identifying subtype specific vulnerability in Hepatocellular Carcinoma
Salary: from £32,868 to £42,717 subject to experience, plus relocation allowance and visa costs if required.
Contract term: Fixed up to 6 years, subject to successful review at Year 3.
The CRUK Beatson Institute where the lab is based is a world leading cancer research institute, situated in the vibrant city of Glasgow in Scotland and hosting approximately 60 postdoctoral researcher scientists at any one time. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned in vivo modelling of tumour growth and metastasis.
A postdoctoral position is offered in the Liver Disease and Regeneration group headed by Professor Tom Bird. As a group we have developed, and now are exploiting, a suite of genetically engineered mouse models of subtypes of Hepatocellular Carcinoma to explore and test the clinical utility of targeting subtype-specific pathways in this common cancer of unmet need.
The project will address the question of why a common and difficult to treat subtype of the disease is resistant to therapy and whether there are specific vulnerabilities that can be exploited during its development to treat it at an earlier stage. This will involve both pathway inhibition and interaction with tumour microenvironment particularly the immune microenvironment.
We work collaboratively with the state-of-the-art facilities throughout the Beatson and additionally with Industrial partners with a very focused view on how we can rapidly deliver novel therapies to clinical trials in patients. The project will involve significant work with animal models but aims to also integrate human multiomic data from project partners. Tissue analysis and experimental planning will be central components of the role also.
You must have a PhD in a relevant field, be ambitious, thorough and driven by scientific curiosity. Exisiting skills with regard to the use of animal models including holding a Personal License (PIL), and bioinformatic methods are especially desirable. A desire to work in translation science is essential.
To find out more about this unique opportunity to establish advanced skills and expertise in this exciting field please contact: Professor Tom Bird, firstname.lastname@example.org.
Postdocs are key members of our research community, and we offer them a range of opportunities to train and develop as researchers while they are with us:
Exciting, innovative cancer research projects in state-of-the art labs
A highly collaborative and interactive research environment
Access to and training in key advanced technologies, for example imaging and in vivo modelling
A mentor enabling scheme to aid personal and professional development
A rich programme of scientific exchange through seminars, workshops and meetings
Support to make fellowship and small grant applications, including during their transition to their next position
Guidance and mentoring to compete for an independent scientist position as well as a multitude of other career options, including in industry.
A highly engaged postdoc forum, providing peer support, training, careers advice and regular social events
Equality, Diversity and Inclusion
Our overarching research ethos at the Institute is about excellence, honesty, openness, accountability and integrity. The diversity of our staff and students is also what makes the Institute such a vibrant place to work and advance discoveries in cancer research. Family friendly policies, our collaborative ethos, a focus on good mental health and well-being and opportunities for all help to create an enjoyable and inclusive workplace where your voice matters.
The Institute is also committed to increasing the number of female scientists at the postdoc level and beyond and encourages female applicants to apply. We have a highly attractive maternity policy which provides 12-18 months support and funding for postdocs wishing to take time off to spend with their children amongst other family friendly policies.
• Competitive salary
• 40.5 days annual leave including bank holidays (pro-rata)
• Defined Contribution pension scheme
• Life Insurance scheme
• Employee Assistance Programme
• Season ticket loan
• Additional maternity pay at 6 month's full pay (subject to service)
• Shared parental leave
• Cycle to work scheme that could save you 26-40% on a bike and accessories.
• Access to Employee benefit schemes with discounts on supermarkets, cinema, travel and much more.
• On-site secure parking
Closing Date for Applications: 05 February 2023. We hope to hold interviews between 20th February and 03 March 2023.