Cell metabolism and Cancer Associated Fibroblasts

Prof Sara Zanivan


Beatson Lab: Tumour Microenvironment and Proteomics
Salary: from £32,868 to £42,717 subject to experience, plus relocation allowance and visa costs if required.
Contract term: Fixed up to 6 years, subject to successful review at Year 3

About us

The CRUK Beatson Institute where the lab is based is a world leading cancer research institute, situated in the vibrant city of Glasgow in Scotland and hosting approximately 60 postdoctoral researcher scientists at any one time. It has an excellent reputation for fundamental cancer research, including world-class metabolism studies and renowned in vivo modelling of tumour growth and metastasis.

Project outline

A postdoctoral position is available in the Tumour Microenvironment & Proteomics group headed by Professor Sara Zanivan. The group is a vibrant team, which aims to understand how cancer-associated fibroblasts (CAFs) influence tumour development and metastatic spread, with a focus on their metabolism. We are currently looking for a highly skilled and motivated postdoc to join our multidisciplinary team to study the roles of cell metabolism in regulating CAF functions important for metastatic dissemination in highly aggressive ovarian and breast cancers (Kay E. et al. Nature Metabolism, in press, https://www.biorxiv.org/content/10.1101/2020.05.30.125237v2.full).

This post will identify and functionally characterise metabolic pathways that control CAF functions important to support their tumour-promoting and immune-modulatory functions. The project involves analysis of our and publicly available omics datasets, heterotypic cell cultures with patient-derived cells, state-of-the-art omics technologies, including MS-based metabolomics and proteomics, and in vivo models.

Applicants must have a PhD in a relevant field, be ambitious and driven by scientific curiosity. Previous experience with regard to cell metabolism is highly recommended, and experience or interest in CAFs, in vivo cancer models and omics data analysis would be an advantage.

To find out more about this unique opportunity to establish advanced skills and expertise in this exciting field please contact: Professor Sara Zanivan s.zanivan@beatson.gla.ac.uk 

Postdoc support

Postdocs are key members of our research community, and we offer them a range of opportunities to train and develop as researchers while they are with us:

  • Exciting, innovative cancer research projects in state-of-the art labs
  • A highly collaborative and interactive research environment
  • Access to and training in key advanced technologies, for example imaging and in vivo modelling
  • A mentor enabling scheme to aid personal and professional development
  • A rich programme of scientific exchange through seminars, workshops and meetings
  • Support to make fellowship and small grant applications, including during their transition to their next position
  • Guidance and mentoring to compete for an independent scientist position as well as a multitude of other career options, including in industry.
  • A highly engaged postdoc forum, providing peer support, training, careers advice and regular social events

Equality, Diversity and Inclusion

Our overarching research ethos at the Institute is about excellence, honesty, openness, accountability and integrity. The diversity of our staff and students is also what makes the Institute such a vibrant place to work and advance discoveries in cancer research. Family friendly policies, our collaborative ethos, a focus on good mental health and well-being and opportunities for all help to create an enjoyable and inclusive workplace where your voice matters.

The Institute is also committed to increasing the number of female scientists at the postdoc level and beyond and encourages female applicants to apply. We have recently introduced a highly attractive maternity policy which provides 12-18 months support and funding for postdocs wishing to take time off to spend with their children amongst other family friendly policies.


Closing Date: 15 July 2022 but we will contact promising candidates on a rolling basis, so please apply as soon as you are ready


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