ACRCelerate Junior Researchers Symposium

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ACRCelerate: Colorectal Cancer Stratified Medicine Network

The ACRCelerate Colorectal Cancer Stratified Medicine Network, led by Prof Owen Sansom, is a European-wide consortium of basic and clinical scientists at the forefront of CRC research. The overarching aim of the ACRCelerate project is to generate robust and reproducible preclinical data, using a suite of state-of-the art preclinical models, to de-risk future clinical trials via patient stratification. 

This is primarily aimed at giving more Junior members, associated with the ACRCelerate network, a chance to present their work, however all members of the ACRCelerate consortium and extended community are invited to attend.

The symposium will consist of short talks by PhD students and postdoctoral researchers and breakout sessions for further discussion of specific topics. There will also be an interactive poster session which will allow as many people as possible to share their research.

The plenary lecture will be given by Mathew Garnett, Wellcome Trust Sanger Centre, Cambridge, UK.

Please register using the following link;

Registration for Junior Researchers Symposium

The conference is FREE to attend.

Numbers will be strictly limited to 120, so please register early to ensure a place (Deadline: 20th August).

Programme

Please note these are UK TIMES.

Wednesday 1st September

ACRCelerate –Junior Researchers Symposium

Gather.Town & Zoom platforms

Session 1

Introduction & Role of TGFb in colorectal cancer

Chairs: Eoghan Mulholland & Simonetta Leto

8.50-9.00am

Owen Sansom - CRUK Beatson Institute, Glasgow.

Welcome & Overview

9.00-9.20am

Dustin Flanagan - CRUK Beatson Institute, Glasgow.

Epithelial TGFβ moonlights as a bad actor in colorectal cancer.

9.20-9.40am

Callum Beach - University of Oxford.

Will TGFB inhibition improve colorectal tumour response to combination immunoradiotherapy.

9.40-10.00am

Carme Cortina - (IRB) Barcelona.

The emergence of facultative stem cells by TGF-β impairment sustains CRC growth.

10.00-10.15am

Coffee Break

Session 2

EGFR and MAPK signalling

Chairs: Tamsin Lannagan & Carme Cortina

10.15-10.35am

Sudhir Malla- Queens University Belfast.

Ontology-led CRC classification uncovers novel pathway-driven tumour subtypes.

10.35-10.55am

Connor Woolley - University of Edinburgh.

Atypical BRAF Mutation in Colorectal Cancer.

10.55- 11.15am

Simonetta Leto- Candiolo Cancer Institute, Turin.

Exploiting patient-derived xenografts and organoids to tackle apoptotic dependencies in EGFR-inhibited colorectal tumours.

11.15-11.35am

Mark White- CRUK Beatson Institute, Glasgow.

Modelling Braf mutant colorectal cancer in GEMMs. 

11.35-11.45am

Comfort Break

11.45-12.30pm

Breakout sessions

A - Models of drug-tolerant cell persistence in colorectal cancer

B - Irradiation: conducting robust pre-clinical experiments

C - Mice & Men: Computational Battle!

12.30-1.00pm

Lunch Break

1.00-2.00pm

Poster Session

2.00-3.00pm

Plenary Lecture (chair: Andrew Campbell)

Mathew Garnett – Wellcome Trust Sanger Centre, Cambridge.

Tumour organoid cultures as a platform for functional genomics.

3.00-3.15pm

Coffee Break

Session 3

Tumour microenvironment

Chairs: Mark White & Sudhir Malla

3.15-3.35pm

Shania Corry- Queens University Belfast.

Activation of STAT1-mediated antigen processing represents a therapeutic vulnerability that can prevent relapse in stroma-rich colon cancer.

3.35-3.55pm

Eoghan Mulholland- University of Oxford.

Colorectal Cancer Cell Communities: Landscape Analysis using multiplex Imaging.

3.55-4.15pm

Sara Verbandt- KU Leuven Belgium.

Epithelial subtypes and relationship to T cell infiltrates in colorectal cancer.

4.15-4.35pm

Antonia Churchhouse - University of Edinburgh.

Loss of Dock2 increases susceptibility to inflammation-associated colorectal cancer in vivo and is associated with an interferon gamma signature.

4.35.-4.45pm

Simon Leedham - University of Oxford.

Closing remarks.

4.45-6.00pm

Informal Discussions in Gather.Town space

 

 

 For further information please email;  ACRCelerate@beatson.gla.ac.uk

 

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