The Liver Metastatic Niche
The McNab Centre for Cancer Innovation
Prof. Laura Machesky - Migration, Invasion and Metastasis
Dr Chiara Braconi - Institute of Cancer Sciences
Spheres composed of hepatocytes, sinusoidal endothelial and/or stellate cells will be used to develop and refine a model of the liver metastatic niche in parallel with analysis from in vivo genetic mouse models and human samples. The unique contribution of the cancer driver mutation(s), cancer types (e.g., pancreatic vs colorectal) will be considered in the context of how new metastases are established and which vulnerabilities might be actionable for new therapies.
To apply, please complete a PhD Studentship Form (in right-hand menu opposite). Application deadline: Sunday 31st October 2021 17.00