The Liver Metastatic Niche

The McNab Centre for Cancer Innovation

Prof. Laura Machesky - Migration, Invasion and Metastasis

Dr Chiara Braconi - Institute of Cancer Sciences

Spheres composed of hepatocytes, sinusoidal endothelial and/or stellate cells will be used to develop and refine a model of the liver metastatic niche in parallel with analysis from in vivo genetic mouse models and human samples. The unique contribution of the cancer driver mutation(s), cancer types (e.g., pancreatic vs colorectal) will be considered in the context of how new metastases are established and which vulnerabilities might be actionable for new therapies.

For informal enquiries or further details on the project, please email Prof. Laura Machesky ( and Dr Chiara Braconi (

To apply, please complete a PhD Studentship Form (in right-hand menu opposite). Application deadline: Sunday 31st October 2021 17.00


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