Recent publications
March 2023
Mahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Uribe AH, Shokry E, Young AL, Lilla S, Kim M, Park T, Manchon JL, Rodriguez-Antona C, Walters RC, Springett RJ, Blaza JN, Zanivan S, Sumpton DA, Roberts EW, Reznik E, Gammage PA. Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade. bioRxiv. 2023;Volume:2023.2003.2021.533091.
Vande Voorde J, Najumudeen AK, Steven RT, Nikula CJ, Dexter A, Zeiger LB, Elia EA, Nassif A, Gonzalez-Fernandez A, Murta T, Gillespie M, Ford CA, Lannagan TRM, Vlahov N, Ridgway RA, Nixon C, Gilroy K, Gay DM, Burton A, Yan B, Sellers K, Wu V, Xiang Y, Shokry E, Clark W, Li VSW, Barry ST, Goodwin RJA, Takats Z, Maddocks ODK, Sumpton D, Yuneva MO, Campbell AD, Bunch J, Sansom OJ. Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. bioRxiv. 2023;Volume:2023.2003.2012.531945.
Villar VH, Allega MF, Deshmukh R, Ackermann T, Nakasone MA, Vande Voorde J, Drake TM, Oetjen J, Bloom A, Nixon C, Müller M, May S, Tan EH, Vereecke L, Jans M, Blancke G, Murphy DJ, Huang DT, Lewis DY, Bird TG, Sansom OJ, Blyth K, Sumpton D, Tardito S. Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology. 2023;19:292-300.
Coffelt SB, Suzuki T. γδ T cells turn the tables on immune-evasive colon cancer. Med. 2023;4:141-142.
Debnath J, Gammoh N, Ryan KM. Autophagy and autophagy-related pathways in cancer. Nat Rev Mol Cell Biol. 2023;10.1038/s41580-023-00585-z:1-16.
Hartley A, Ahmad I. The role of PPARγ in prostate cancer development and progression. Br J Cancer. 2023;128:940-945.
Machesky LM. CYRI proteins: controllers of actin dynamics in the cellular 'eat vs walk' decision. Biochem Soc Trans. 2023;10.1042/bst20221354.
Machesky LM. Deadly actin collapse by disulfidptosis. Nat Cell Biol. 2023;25:375-376.
Marchi S, Guilbaud E, Tait SWG, Yamazaki T, Galluzzi L. Mitochondrial control of inflammation. Nat Rev Immunol. 2023;23:159-173.
Vringer E, Tait SWG. Mitochondria and cell death-associated inflammation. Cell Death Differ. 2023;30:304-312.
February 2023
Román-Fernández A, Mansour MA, Kugeratski FG, Anand J, Sandilands E, Galbraith L, Rakovic K, Freckmann EC, Cumming EM, Park J, Nikolatou K, Lilla S, Shaw R, Strachan D, Mason S, Patel R, McGarry L, Katoch A, Campbell KJ, Nixon C, Miller CJ, Leung HY, Le Quesne J, Norman JC, Zanivan S, Blyth K, Bryant DM. Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Sci Adv. 2023;9:eabq1858.
Sandilands E, Freckmann EC, Cumming EM, Román-Fernández A, McGarry L, Anand J, Galbraith L, Mason S, Patel R, Nixon C, Cartwright J, Leung HY, Blyth K, Bryant DM. The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. Journal of Cell Biology. 2023;222.
Barry ST, Gabrilovich DI, Sansom OJ, Campbell AD, Morton JP. Therapeutic targeting of tumour myeloid cells. Nat Rev Cancer. 2023;10.1038/s41568-022-00546-2.
Heilig R, Lee J, Tait SWG. Mitochondrial DNA in cell death and inflammation. Biochem Soc Trans. 2023;10.1042/bst20221525.
Insall R. Science Twitter - navigating change in science communication. Nat Rev Mol Cell Biol. 2023;10.1038/s41580-023-00581-3.
Kay EJ, Zanivan S. Bicarbonate transport as regulator of anti-tumour immunity in pancreatic cancer. Mol Oncol. 2023;10.1002/1878-0261.13400.
Khan AS, Campbell KJ, Cameron ER, Blyth K. The RUNX/CFBβ Complex in Breast Cancer: A Conundrum of Context. Cells. 2023;12.
May S, Bird TG. How the liver keeps itself in shape. Elife. 2023;12.
Nössing C, Ryan KM. 50 years on and still very much alive: 'Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics'. Br J Cancer. 2023;128:426-431.
Ryan KM. Data sharing and management in 21st century cancer research. Mol Oncol. 2023;10.1002/1878-0261.13385.
Shaw AM, Gammage PA. Coupling Differential Centrifugation with Exonuclease Treatment and Size Exclusion Chromatography (DIFSEC) for Purification of mtDNA from Mammalian Cells. Methods Mol Biol. 2023;2615:31-40.
January 2023
Amirkhah R, Gilroy K, Malla SB, Lannagan TRM, Byrne RM, Fisher NC, Corry SM, Mohamed N-E, Naderi-Meshkin H, Mills ML, Campbell AD, Ridgway RA, Ahmaderaghi B, Murray R, Llergo AB, Sanz-Pamplona R, Villanueva A, Batlle E, Salazar R, Lawler M, Sansom OJ, Dunne PD. MmCMS: mouse models’ consensus molecular subtypes of colorectal cancer. British Journal of Cancer. 2023;10.1038/s41416-023-02157-6.
Brown G, Soloviev D, Lewis DY. Radiosynthesis and Analysis of (S)-4-(3-[(18)F]Fluoropropyl)-L-Glutamic Acid. Mol Imaging Biol. 2023;10.1007/s11307-022-01793-3.
Edwards SC, Hedley A, Hoevenaar WHM, Wiesheu R, Glauner T, Kilbey A, Shaw R, Boufea K, Batada N, Hatano S, Yoshikai Y, Blyth K, Miller C, Kirschner K, Coffelt SB. PD-1 and TIM-3 differentially regulate subsets of mouse IL-17A-producing γδ T cells. J Exp Med. 2023;220.
May S, Müller M, Livingstone CR, Skalka GL, Walsh PJ, Nixon C, Hedley A, Shaw R, Clark W, Voorde JV, Officer-Jones L, Ballantyne F, Powley IR, Drake TM, Kiourtis C, Keith A, Rocha AS, Tardito S, Sumpton D, Le Quesne J, Bushell M, Sansom OJ, Bird TG. Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration. J Hepatol. 2023;10.1016/j.jhep.2023.01.009
Rushworth LK, Loveridge C, Salji M, MacLeod M, Mui E, Sumpton D, Neilson M, Hedley A, Alexander L, McCartney E, Patel R, Wallace J, Delles C, Jones R, Leung HY. Phase II proof-of-concept study of atorvastatin in castration-resistant prostate cancer. BJU Int. 2023;131:236-243.
Santi A, Kay EJ, Neilson LJ, McGarry L, Lilla S, Mullin M, Paul NR, Fercoq F, Koulouras G, Blanco GR, Athineos D, Mason S, Hughes M, Kieffer Y, Nixon C, Blyth K, Mechta-Grigoriou F, Carlin LM, Zanivan S. Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function. bioRxiv. 2023;Volume:2023.2001.2013.523951.
Schmidt T, Dabrowska A, Waldron JA, Hodge K, Koulouras G, Gabrielsen M, Munro J, Tack DC, Harris G, McGhee E, Scott D, Carlin Leo M, Huang D, Le Quesne J, Zanivan S, Wilczynska A, Bushell M. eIF4A1-dependent mRNAs employ purine-rich 5’UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation. Nucleic Acids Research. 2023;10.1093/nar/gkad030.
Coffelt SB, Morton JP. LOXL2 in pancreatic tumourigenesis: the complexity of tumour-stromal crosstalk exemplified. Gut. 2023;72:221-222.
December 2022
Dowdell A, Paschke P, Thomason P, Tweedy L, Insall RH. Competition between chemoattractants causes unexpected complexity and can explain negative chemotaxis. bioRxiv. 2022;10.1101/2022.12.07.519354:2022.2012.2007.519354.
Flanagan DJ, Amirkhah R, Vincent DF, Gundaz N, Gentaz P, Cammareri P, McCooey AJ, McCorry AMB, Fisher NC, Davis HL, Ridgway RA, Lohuis J, Leach JDG, Jackstadt R, Gilroy K, Mariella E, Nixon C, Clark W, Hedley A, Markert EK, Strathdee D, Bartholin L, Redmond KL, Kerr EM, Longley DB, Ginty F, Cho S, Coleman HG, Loughrey MB, Bardelli A, Maughan TS, Campbell AD, Lawler M, Leedham SJ, Barry ST, Inman GJ, van Rheenen J, Dunne PD, Sansom OJ. Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features. Nat Commun. 2022;13:7551.
Grotehans N, McGarry L, Nolte H, Kroker M, Narbona-Perez AJ, Deshwal S, Giavalisco P, Langer T, MacVicar T. Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression. bioRxiv. 2022;Volume:2022.2011.2029.518352.
Soloviev D, Dzien P, Mackintosh A, Malviya G, Brown G, Lewis D. High molar activity [(18)F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET. EJNMMI Radiopharm Chem. 2022;7:32.
Papalazarou V, Drew J, Juin A, Spence HJ, Whitelaw J, Nixon C, Salmeron-Sanchez M, Machesky LM. Collagen VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche. J Cell Sci. 2022;135.
Taralli S, Quartuccio N, Malviya G. Editorial: Case reports in PET imaging. Front Med (Lausanne). 2022;9:1087583.
November 2022
October 2022
Bader AS, Luessing J, Hawley BR, Skalka GL, Lu W-T, Lowndes Noel F, Bushell M. DDX17 is required for efficient DSB repair at DNA:RNA hybrid deficient loci. Nucleic Acids Research. 2022;10.1093/nar/gkac843.
McGarry DJ, Castino G, Lilla S, Carnet A, Kelly L, Micovic K, Zanivan S, Olson MF. MICAL1 activation by PAK1 mediates actin filament disassembly. Cell Reports. 2022;41.
Sansom O. A new network for the synergistic translation of mouse research. Dis Model Mech. 2022;15.
September 2022
Fisher NC, Byrne RM, Leslie H, Wood C, Legrini A, Cameron AJ, Ahmaderaghi B, Corry SM, Malla SB, Amirkhah R, McCooey AJ, Rogan E, Redmond KL, Sakhnevych S, Domingo E, Jackson J, Loughrey MB, Leedham S, Maughan T, Lawler M, Sansom OJ, Lamrock F, Koelzer VH, Jamieson NB, Dunne PD. Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data. Clinical Cancer Research. 2022;28:4056-4069.
Freckmann EC, Sandilands E, Cumming E, Neilson M, Román-Fernández A, Nikolatou K, Nacke M, Lannagan TRM, Hedley A, Strachan D, Salji M, Morton JP, McGarry L, Leung HY, Sansom OJ, Miller CJ, Bryant DM. Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nat Commun. 2022;13:5317.
Singh SP, Paschke P, Tweedy L, Insall RH. AKT and SGK kinases regulate cell migration by altering Scar/WAVE complex activation and Arp2/3 complex recruitment. Front Mol Biosci. 2022;9:965921
Devlin R, Roberts E. Building a healthy mouse model ecosystem to interrogate cancer biology. Dis Model Mech. 2022;15(9).
Kugeratski FG, Santi A, Zanivan S. Extracellular vesicles as central regulators of blood vessel function in cancer. Science Signaling. 2022;15(753):eaaz4742.
August 2022
Kowalczyk D, Nakasone MA, Smith BO, Huang DT. Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function. Life Sci Alliance. 2022;5(12).
Kim M, Mahmood M, Reznik E, Gammage PA. Mitochondrial DNA is a major source of driver mutations in cancer. Trends in Cancer. 2022;
July 2022
Gioelli N, Neilson LJ, Wei N, Villari G, Chen W, Kuhle B, Ehling M, Maione F, Willox S, Brundu S, Avanzato D, Koulouras G, Mazzone M, Giraudo E, Yang XL, Valdembri D, Zanivan S, Serini G. Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability. Nat Commun. 2022;13:4188.
Knight JRP, Proud CG, Mallucci G, Haar TV, Smales CM, Willis AE, Sansom OJ. eEF2K activity is required for the phenotypes of the Rpl24(Bst) mouse. J Invest Dermatol. 2022;10.1016/j.jid.2022.06.019.
Long JS, Kania E, McEwan DG, Barthet VJA, Brucoli M, Ladds M, Nössing C, Ryan KM. ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis. Proc Natl Acad Sci U S A. 2022;119:e2113465119.
Robertson NA, Latorre-Crespo E, Terradas-Terradas M, Lemos-Portela J, Purcell AC, Livesey BJ, Hillary RF, Murphy L, Fawkes A, MacGillivray L, Copland M, Marioni RE, Marsh JA, Harris SE, Cox SR, Deary IJ, Schumacher LJ, Kirschner K, Chandra T. Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects. Nature Medicine. 2022;10.1038/s41591-022-01883-3.
Cartwright D, White M, Crearie C, Forte C, Coulter S, Brown J, Randhawa M, Glasspool R, Roxburgh P. Letter comments on: Glomerular filtration rate estimation for carboplatin dosing in patients with gynaecological cancers. ESMO Open. 2022;7:100533.
June 2022
Baudot AD, Wang VM, Leach JD, O'Prey J, Long JS, Paulus-Hock V, Lilla S, Thomson DM, Greenhorn J, Ghaffar F, Nixon C, Helfrich MH, Strathdee D, Pratt J, Marchesi F, Zanivan S, Ryan KM. Glycan degradation promotes macroautophagy. Proc Natl Acad Sci U S A. 2022;119(26):e2111506119.
Kay EJ, Paterson K, Riero-Domingo C, Sumpton D, Däbritz JHM, Tardito S, Boldrini C, Hernandez-Fernaud JR, Athineos D, Dhayade S, Stepanova E, Gjerga E, Neilson LJ, Lilla S, Hedley A, Koulouras G, McGregor G, Jamieson C, Johson RM, Park M, Kirschner K, Miller C, Kamphorst JJ, Loayza-Puch F, Saez-Rodriguez J, Mazzone M, Blyth K, Zagoni M, Zanivan S. Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature Metabolism. 2022;4(6):693-710.
Patel R, Ford CA, Rodgers L, Rushworth LK, Fleming J, Mui E, Zhang T, Watson D, Lynch V, Mackay G, Sumpton D, Sansom OJ, Vande Voorde J, Leung HY. Cyclocreatine suppresses creatine metabolism and impairs prostate cancer progression. Cancer Res. 2022;82:2565–2575
Suzuki T, Kilbey A, Ridgway RA, Hayman H, Byrne R, Casa Rodriguez N, Georgakopoulou A, Chen L, Verzi M, Gay DM, Vzquez EG, Belnoue-Davis HL, Gilroy K, Kostner AH, Kersten C, Thuwajit C, Andersen D, Wiesheu R, Jandke A, Roberts N, Blyth K, Roseweir A, Leedham SJ, Dunne PD, Edwards J, Hayday A, Sansom OJ, Coffelt SB. β-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expression. bioRxiv. 2022;Volume:2022.2006.2010.495115.
Taurino G, Deshmukh R, Villar VH, Chiu M, Shaw R, Hedley A, Shokry E, Sumpton D, Dander E, D'Amico G, Bussolati O, Tardito S. Mesenchymal stromal cells cultured in physiological conditions sustain citrate secretion with glutamate anaplerosis. Mol Metab. 2022:101532
Bon M, Bilsland A, Bower J, McAulay K. Fragment-Based Drug Discovery - The Importance of High Quality Molecule Libraries. Mol Oncol. 2022.
May 2022
Buracco S, Singh S, Claydon S, Paschke P, Tweedy L, Whitelaw J, McGarry L, Thomason PA, Insall RH. The Scar/WAVE complex drives normal actin protrusions without the Arp2/3 complex, but proline-rich domains are required. bioRxiv. 2022;Volume:2022.2005.2014.491902.
Curio S, Edwards SC, Suzuki T, McGovern J, Triulzi C, Yoshida N, Jonsson G, Glauner T, Rami D, Wiesheu R, Kilbey A, Purcell RV, Coffelt SB, Guerra N. NKG2D signaling regulates IL-17A-producing γδT cells in mice to promote cancer progression. Discovery Immunology. 2022;10.1093/discim/kyac002.
Bravo-Blas A, Pirillo C, Shergold A, Andrusaite A, Roberts EW. Think global but act local: Tuning the dendritic cell response in cancer. The International Journal of Biochemistry & Cell Biology. 2022;147:106227.
Tait SWG. Killing cells using light (activated) sabers. Journal of Cell Biology. 2022;221:e202205018
April 2022
Cao K, Riley JS, Heilig R, Montes-Gómez AE, Vringer E, Berthenet K, Cloix C, Elmasry Y, Spiller DG, Ichim G, Campbell KJ, Gilmore AP, Tait SWG. Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage. Developmental Cell. 2022;57:1211-1225
Humpton TJ, Hall H, Kiourtis C, Nixon C, Clark W, Hedley A, Shaw R, Bird TG, Blyth K, Vousden KH. p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl(4). Cell Death Differ. 2022;29:514-526.
Koessinger AL, Cloix C, Koessinger D, Heiland DH, Bock FJ, Strathdee K, Kinch K, Martínez-Escardó L, Paul NR, Nixon C, Malviya G, Jackson MR, Campbell KJ, Stevenson K, Davis S, Elmasry Y, Ahmed A, O’Prey J, Ichim G, Schnell O, Stewart W, Blyth K, Ryan KM, Chalmers AJ, Norman JC, Tait SWG. Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics. Cell Death & Differentiation. 2022;10.1038/s41418-022-01001-3.
Le AH, Machesky LM. Image-based Quantification of Macropinocytosis Using Dextran Uptake into Cultured Cells. Bio Protoc. 2022;12:e4367.
Coffelt SB, Morton JP. LOXL2 in pancreatic tumourigenesis: the complexity of tumour-stromal crosstalk exemplified. Gut. 2022;10.1136/gutjnl-2022-327430.
Barthet VJA, Ryan KM. DRAMs and autophagy: a family affair. Autophagy Reports. 2022;1:170-174.
Lawrence M, Wiesheu R, Coffelt SB. The duplexity of unconventional T cells in cancer. The International Journal of Biochemistry & Cell Biology. 2022;146:106213.
