Boost for Preclinical Cancer Modelling at the Beatson
MRC announces £2.9 million investment into furthering cancer research
Today the MRC National Mouse Genetics Network is announcing a multi-million pound backing of mouse genetics for disease modelling. It will capitalise on the UK's international excellence in the biomedical sciences, creating 7 challenge-led research clusters.
Beatson Scientists’ images excite at Cell Worlds exhibition
A new science and art project boldly takes microscopy images where they have never gone before
Scientists as the camerawomen and -men of the unknown is the motto of a recently founded educational project. Bringing together art and science, Cell Worlds now stages an immersive experience in Bordeaux, France of the microscopic world of the human body – told through state-of-the-art fluorescent images by expert scientists like Dr Anh Hoang Le and Prof Laura Machesky at the Beatson.
Tom MacVicar and Vicky Cowling join the Beatson Institute
We would like to extend a warm welcome to Dr Tom MacVicar, who recently took up a junior group leader position at the Beatson. Tom has joined us from the Max Planck Institute for Biology of Ageing in Cologne to establish his first independent research group here in Glasgow.
Publication Highlights: Feb 2022
In the Journal of Medicinal Chemistry, Tamas Yelland and Esther Garcia presented a novel, alternative KRAS targeting strategy - tagging it for relocation to the cytoplasm. While sustaining KRAS binding to the protein PDE6D, KRAS moved away from its usual site of action at the cell membrane, leading to reduced downstream KRAS-oncogenic signalling. As the levels of the two proteins naturally vary between cell types, further study is required to develop a KRAS:PDE6D stabiliser that could be used as a successful anti-cancer therapy.
SCOTTISH SCIENTISTS GET £12 MILLION BOOST FROM CANCER RESEARCH UK
Multimillion-pound investment in Scottish cancer research is welcomed by bowel cancer survivor, Iain, from Helensburgh
SCOTS scientists are set to receive a major cash injection from Cancer Research UK.
Publication Highlights: Dec 2021/Jan 2022
Translation, a process during protein synthesis, could be a potential target for anti-tumour therapy in colorectal cancer (CRC), as suggested by John Knight and colleagues in their recent study – 'Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K'. They investigated an impairment of the protein production machinery, a mutation in the ribosomal subunit Rpl24, in a KRAS- and APC-driven model of CRC - not only did this reduce the overall rate of protein production within tumours, but it also affected tumour growth and development. When studying human tissue, the same signalling pathway, centred around the eEF2 component and its activation, was identified in tumour samples, and hence, its proposed role as a drug-relevant pathway.
New CRUK Scotland Centre announced
From April, Scotland will become one of seven Cancer Research UK Centres across the UK. The funding provided will help translate cutting-edge discoveries from laboratories in Edinburgh and Glasgow, including those at the Beatson, into direct benefits for cancer patients.
Inspiring women: Editors in the spotlight
Great to hear about Prof Karen Blyth's experience of women in STEM as an editor for an Elsevier journal.
Six editorial team members of Gene, including Karen, were interviewed about the journal, their careers and the role of women in science: https://www.elsevier.com/life-sciences/biochemistry-genetics-and-molecular-biology/journals/editor-spotlight-meet-the-women-behind-leading-genetics-journals
Spotlight on: Histology Lab Manager Colin Nixon
At the Beatson Institute, we are fortunate in being supported by some outstanding core services. These include our Histology Service, which is managed by Colin Nixon who was recently interviewed for a Spotlight in Science article. This feature provides a great opportunity to find out about Colin's career path to his current role and the exciting work his team is doing.
Beatson researchers featured in Cancer Grand Challenges’ annual celebration of scientific progress
Beatson Director Owen Sansom and postdoctoral fellow Arafath Najumudeen have been featured in Cancer Grand Challenges' annual progress magazine, Discover – a celebration of the advances against cancer that can be made when diverse, global teams come together and think differently.
Spotlight on: Professor Danny Huang
The discovery in the 1970s that certain proteins are ubiquitinated before degradation was awarded the 2004 Nobel Prize in Chemistry. Ubiquitination has increasingly been recognised as important in various cell functions. Its best-known function is as a mediator of protein degradation: the tagging of a protein with ubiquitin marks it for degradation by the proteasome.
Publication Highlights: August 2021
Together with other Beatson scientists, Joseph Hodgson and Jean-Philippe Parvy added to the expanding field of cancer cachexia [Drosophila Larval Models of Invasive Tumorigenesis for In Vivo Studies on Tumour/Peripheral Host Tissue Interactions during Cancer Cachexia]. In fly larvae models, they showed that cancer-associated tissue wasting was unrelated to food intake and tumour size, but instead was dependent on the genetic make-up of the tumour. Their findings led them to develop a new model system for cachexia where tumour and muscle can be manipulated separately. This will aid further insights into tissue interactions.
Publication Highlights: July 2021
Neutrophils – which are associated with poor outcomes in cancer – come in many different types. Reliable cell surface markers are needed to distinguish and study these different populations of neutrophils. In a study released in bioRxiv (Maturation, developmental site, and pathology dictate murine neutrophil function), Postdoc John Mackey identified a protein called Ly6G as one such marker. Importantly, having an abundance of cells expressing medium levels of Ly6G was associated with higher rates of metastasis. The team also identified that the site where neutrophils develop – either the bone marrow or the spleen – affects the genes they express and their functional capacity.
Beatson announces details of its vision and aims for EDI
The CRUK Beatson Institute is committed to promoting equality, diversity and inclusion (EDI) within our community. We value equity in our actions and deeds, diversity and inclusion within our workforce and collaborators, and the diversity of thought this brings. Read more about our vision and aims for EDI here, including our leading family friendly policies on maternity and shared parental leave.
Beatson International Cancer Conference 2021
31st July 2021
We would like to extend a warm thank you to everyone who made our 2021 virtual conference 'The Cartography of Cancer: Mapping Tumours in 3D' a great success. We had a series of fantastic talks covering areas from the tumour microenvironment to immunology, mutation and metabolic mapping.
Embedding research integrity at the core of our science
28th July 2021
Cancer Research UK has deepened its commitment to good research practice by becoming a signatory of the Concordat to Support Research Integrity. In their recent blog post, they speak two Research Integrity Advisers - Dr Catherine Winchester, CRUK Beatson Institute and Dr Andrew Porter, CRUK Manchester Institute - to find out why supporting scientists to be the best they can be is the only way to ensure quality research...
Read more here: https://news.cancerresearchuk.org/2021/07/28/embedding-research-integrity-at-the-core-of-our-science/
New license agreement signed with Sitryx
06th July 2021
Sitryx, a biopharmaceutical company focused on immunometabolism, has entered into a license agreement with Cancer Research UK to develop IP from the Beatson Institute's Drug Discovery Unit relating to small molecule inhibitors of a target kinase, which plays a critical role in a metabolic pathway of emerging importance in immune cells and inflammatory processes: https://www.sitryx.com/news/sitryx-licenses-intellectual-property-rights-for-inhibitors-of-a-new-target-in-immunometabolism-from-cancer-research-uk-in-exclusive-worldwide-agreement
Publication Highlights: June 2021
05th July 2021
This month, we were delighted to see the translation of doctoral research into three outstanding scientific publications.
Kirsteen Campbell receives major award to investigate advanced prostate cancer
30th June 2021
Prostate cancer is the most commonly diagnosed cancer in the UK, for example it affects 1 in 10 men in Scotland. Glasgow-based scientist Dr Kirsteen Campbell, from the Cancer Research UK Beatson Institute, has just received a major award of £273,534 from the charity Prostate Cancer Research (PCR) to investigate if a protein called MCL-1 could lead to new treatment options.
In Conversation with Owen Sansom and Helen Matthews
Patient advocate Helen Matthews met with Owen Sansom to discuss the latest findings of the Cancer Grand Challenge project SPECIFICANCER, which aims to understand why mutations in certain genes only cause cancer in specific parts of the body.
